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Literature summary for 2.7.1.40 extracted from

  • Etges, R.; Mukkada, A.J.
    Purification and characterization of a metabolite-regulated pyruvate kinase from Leishmania major promastigotes (1988), Mol. Biochem. Parasitol., 27, 281-289.
    View publication on PubMed
Search for more literature for 2.7.1.40

Activating Compound

Activating Compound Comment Organism Structure
D-fructose 1,6-diphosphate activation Leishmania major

Inhibitors

Inhibitors Comment Organism Structure
ATP strong Leishmania major
citrate
-
 Leishmania major
GTP
-
 Leishmania major
ITP
-
 Leishmania major
additional information no inhibition by several amino acids Leishmania major

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetic study Leishmania major

Metals/Ions

Metals/Ions Comment Organism Structure
K+ activation Leishmania major
Mg2+ activation Leishmania major

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
59000
-
 x * 59000 Leishmania major
181000
-
-
 Leishmania major

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADP + phosphoenolpyruvate Leishmania major involved in regulation of metabolism of an aerobic organism capable of net glucose synthesis ATP + pyruvate
-
 ?
ADP + phosphoenolpyruvate Leishmania major allosteric enzyme ATP + pyruvate
-
 ?

Organism

Organism UniProt Comment Textmining
Leishmania major
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Leishmania major

Source Tissue

Source Tissue Comment Organism Textmining
promastigote
-
 Leishmania major
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + phosphoenolpyruvate positive cooperativity for phosphoenolpyruvate Leishmania major ATP + pyruvate
-
 ?
ADP + phosphoenolpyruvate involved in regulation of metabolism of an aerobic organism capable of net glucose synthesis Leishmania major ATP + pyruvate
-
 ?
ADP + phosphoenolpyruvate allosteric enzyme Leishmania major ATP + pyruvate
-
 ?

Subunits

Subunits Comment Organism
? x * 59000 Leishmania major

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 in the absence of fructose 1,6-diphosphate Leishmania major
7.6
-
 in the presence of fructose 1,6-diphosphate Leishmania major