Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.4 extracted from

  • Lanaspa, M.A.; Sanchez-Lozada, L.G.; Cicerchi, C.; Li, N.; Roncal-Jimenez, C.A.; Ishimoto, T.; Le, M.; Garcia, G.E.; Thomas, J.B.; Rivard, C.J.; Andres-Hernando, A.; Hunter, B.; Schreiner, G.; Rodriguez-Iturbe, B.; Sautin, Y.Y.; Johnson, R.J.
    Uric acid stimulates fructokinase and accelerates fructose metabolism in the development of fatty liver (2012), PLoS ONE, 7, e47948.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.4

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-
liver
-
 Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
fructokinase
-
 Homo sapiens
fructokinase
-
 Rattus norvegicus
KHK
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus hepatic KHK and AldoB expression are increased 2.7fold and 1.8fold, respectively, in fructose-fed rats compared to control rats up
Homo sapiens uric acid up-regulates KHK expression thus leading to the amplification of the lipogenic effects of fructose up