Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.39 extracted from

  • Burr, B.; Walker, J.; Truffa-Bachi, P.; Cohen, G.N.
    Homoserine kinase from Escherichia coli K12 (1976), Eur. J. Biochem., 62, 519-526.
    View publication on PubMed
Search for more literature for 2.7.1.39

Inhibitors

Inhibitors Comment Organism Structure
2-chloro-L-alanine
-
 Escherichia coli
L-2-aminobutyrate
-
 Escherichia coli
L-Cys
-
 Escherichia coli
L-homocysteine
-
 Escherichia coli
L-Ile
-
 Escherichia coli
L-Met
-
 Escherichia coli
L-Ser
-
 Escherichia coli
L-Thr competitive to the substrate L-homoserine Escherichia coli
L-Val
-
 Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.24
-
 L-homoserine pH 7.8, 37°C Escherichia coli
0.55
-
 ATP pH 7.8, 37°C Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ high requirement Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
29000
-
 2 * 29000, SDS-PAGE Escherichia coli
60000
-
 gel filtration Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
 K-12
-
Escherichia coli
-
 derepressed strain
-

Purification (Commentary)

Purification (Comment) Organism
-
 Escherichia coli

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-homoserine
-
 Escherichia coli ADP + O-phospho-L-homoserine
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 29000, SDS-PAGE Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.4
-
 L-2-aminobutyrate pH 7.8, 37°C Escherichia coli
0.6
-
 L-Thr pH 7.8, 37°C Escherichia coli
1
-
 L-Cys pH 7.8, 37°C Escherichia coli
4
-
 L-homocysteine pH 7.8, 37°C Escherichia coli
4.5
-
 L-Ile pH 7.8, 37°C Escherichia coli
10
-
 L-Val pH 7.8, 37°C Escherichia coli
15
-
 2-chloro-L-alanine pH 7.8, 37°C Escherichia coli
27
-
 L-Ser pH 7.8, 37°C Escherichia coli
35
-
 L-Met pH 7.8, 37°C Escherichia coli