Literature summary for 2.7.1.36 extracted from

Li, M.; Min, W.; Wang, J.; Wang, L.; Li, Y.; Zhou, N.; Yang, Z.; Qian, Q.
Effects of mevalonate kinase interference on cell differentiation, apoptosis, prenylation and geranylgeranylation of human keratinocytes are attenuated by farnesyl pyrophosphate or geranylgeranyl pyrophosphate (2020), Exp. Therap. Med., 19, 2861-2870 .

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Cloned(Commentary)

Cloned (Comment)	Organism
the mevalonate kinase (MVK) gene has 10 coding exons and one non-coding exon at chromosome 12q24, the MVK protein is encoded by two transcripts of MVK. Recombinant expression of the enzyme in HaCat human keratinocytes using viral vectors, quantitative reverse transcription-PCR enzyme expression analysis	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	recombinant expression of the enzyme in HaCat human keratinocytes causes interference with the expression of other genes. The mRNA and protein expression levels of keratin 1 and involucrin are significantly decreased following interference of MVK expression, and the decrease is markedly attenuated by farnesyl diphosphate (FPP). Furthermore, the apoptotic rate is markedly increased following MVK interference, and the increase is significantly attenuated by geranylxadgeranyl diphosphate (GGPP). Overexpression of MVK significantly decreased the apoptotic rate of HaCat cells. The prenylation levels after MVK interference is notably decreased, which is markedly attenuated by GGPP. The overexpression of MVK significantly increased the prenylation levels of HaCat cells. FPP or GGPP reverse MVK interference-induced decrease in geranylgeranylation levels of lamin A, HRAS, KRAS, NRAS, Rho E, Rho B, Rho A, RAC1 and cdc42	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	required	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + (R)-mevalonate	Homo sapiens	-	ADP + (R)-5-phosphomevalonate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q03426	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HaCaT cell	-	Homo sapiens	-
keratinocyte	-	Homo sapiens	-
additional information	MVK is ubiquitously expressed	Homo sapiens	-
skin	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + (R)-mevalonate	-	Homo sapiens	ADP + (R)-5-phosphomevalonate	-	?

Synonyms

Synonyms	Comment	Organism
MVK	-	Homo sapiens

General Information

General Information	Comment	Organism
metabolism	MVK functions downstream of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMG-CoA) in the mevalonate pathway. The mevalonate pathway provides crucial molecules to cells, and may be an important metabolic pathway in human skin. Short-chain isoprenoids farnesyl diphosphate (FPP) and geranylgeranyl diphosphate (GGPP) are the intermediate products of the mevalonate pathway, these attach to small G proteins covalently, and serve as molecular switches in many biochemical pathways	Homo sapiens
physiological function	MVK catalyzes the phosphorylation of mevalonic acid into 5-phosphomevalonate, and functions downstream of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMG-CoA) in the mevalonate pathway. The mevalonate pathway provides crucial molecules to cells, and may be an important metabolic pathway in human skin. Analysis of the role of MVK in differentiation, apoptosis and prenylation of keratinocytes, and in the expression of keratin 1 and involucrin, protein prenylation and the processing of small G proteins, overview	Homo sapiens

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Release 2023.1 (January 2023)