Literature summary for 2.7.1.36 extracted from

Gray, J.C.; Kekwick, R.G.O.
The inhibition of plant mevalonate kinase preparations by prenyl pyrophosphates (1972), Biochim. Biophys. Acta, 279, 290-296.

Search for more literature for 2.7.1.36

Inhibitors

Inhibitors	Comment	Organism	Structure
farnesyl diphosphate	-	Cucumis melo
farnesyl diphosphate	-	Hevea brasiliensis
farnesyl diphosphate	-	Phaseolus vulgaris
farnesyl diphosphate	-	Saccharomyces cerevisiae
geranyl diphosphate	-	Cucumis melo
geranyl diphosphate	-	Hevea brasiliensis
geranyl diphosphate	-	Phaseolus vulgaris
geranyl diphosphate	-	Saccharomyces cerevisiae
geranylgeranyl diphosphate	-	Cucumis melo
geranylgeranyl diphosphate	-	Hevea brasiliensis
geranylgeranyl diphosphate	-	Phaseolus vulgaris
geranylgeranyl diphosphate	-	Saccharomyces cerevisiae
phytyl diphosphate	-	Cucumis melo
phytyl diphosphate	-	Hevea brasiliensis
phytyl diphosphate	-	Phaseolus vulgaris
phytyl diphosphate	-	Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
1.5	-	ATP	pH 7.0, 30°C	Phaseolus vulgaris
2	-	ATP	pH 7.0, 30°C	Hevea brasiliensis
5.4	-	ATP	pH 7.0, 30°C	Cucumis melo
7.4	-	ATP	pH 7.0, 30°C	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Cucumis melo	-	-	-
Hevea brasiliensis	-	-	-
Phaseolus vulgaris	-	-	-
Saccharomyces cerevisiae	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cotyledon	-	Phaseolus vulgaris	-
cotyledon	-	Cucumis melo	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.014	-	-	Cucumis melo
0.084	-	-	Phaseolus vulgaris
0.42	-	-	Hevea brasiliensis
0.77	-	-	Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + mevalonate	-	Phaseolus vulgaris	ADP + phosphomevalonate	-	?
ATP + mevalonate	-	Saccharomyces cerevisiae	ADP + phosphomevalonate	-	?
ATP + mevalonate	-	Hevea brasiliensis	ADP + phosphomevalonate	-	?
ATP + mevalonate	-	Cucumis melo	ADP + phosphomevalonate	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0013	-	farnesyl diphosphate	pH 7.0, 30°C	Saccharomyces cerevisiae
0.0023	-	geranyl diphosphate	pH 7.0, 30°C	Saccharomyces cerevisiae
0.0036	-	phytyl diphosphate	pH 7.0, 30°C	Phaseolus vulgaris
0.0039	-	phytyl diphosphate	pH 7.0, 30°C	Hevea brasiliensis
0.0052	-	farnesyl diphosphate	pH 7.0, 30°C	Hevea brasiliensis
0.0071	-	farnesyl diphosphate	pH 7.0, 30°C	Phaseolus vulgaris
0.009	-	phytyl diphosphate	pH 7.0, 30°C	Saccharomyces cerevisiae
0.011	-	farnesyl diphosphate	pH 7.0, 30°C	Cucumis melo
0.016	-	phytyl diphosphate	pH 7.0, 30°C	Cucumis melo
0.018	-	geranyl diphosphate	pH 7.0, 30°C	Hevea brasiliensis
0.022	-	geranylgeranyl diphosphate	pH 7.0, 30°C	Saccharomyces cerevisiae
0.028	-	geranyl diphosphate	pH 7.0, 30°C	Cucumis melo
0.031	-	geranyl diphosphate	pH 7.0, 30°C	Phaseolus vulgaris
0.049	-	geranylgeranyl diphosphate	pH 7.0, 30°C	Phaseolus vulgaris
0.049	-	geranylgeranyl diphosphate	pH 7.0, 30°C	Hevea brasiliensis
0.115	-	geranylgeranyl diphosphate	pH 7.0, 30°C	Cucumis melo

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Release 2023.1 (January 2023)