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Literature summary for 2.7.1.36 extracted from
- Mevalonate kinase (1985), Methods Enzymol., 110, 71-78.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| farnesyl diphosphate | - |
Hevea brasiliensis |  |
| farnesyl diphosphate | - |
Phaseolus vulgaris | |
| farnesyl diphosphate | potent inhibitor | Sus scrofa | |
| geranyl diphosphate | - |
Hevea brasiliensis | |
| geranyl diphosphate | - |
Phaseolus vulgaris | |
| geranyl diphosphate | potent inhibitor | Sus scrofa | |
| additional information | - |
Hevea brasiliensis | |
| additional information | not inhibited by isopentenyl and dimethyldiphosphate and phosphate | Sus scrofa |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | substrate MgATP | Phaseolus vulgaris | |
| Mg2+ | substrate MgATP | Staphylococcus aureus | |
| Mg2+ | substrate MgATP | Rattus norvegicus | |
| Mg2+ | substrate MgATP | Sus scrofa | |
| Mg2+ | substrate MgATP | Saccharomyces cerevisiae | |
| Mg2+ | substrate MgATP | Oryctolagus cuniculus | |
| Mg2+ | substrate MgATP | Pinus radiata | |
| Mg2+ | substrate MgATP | Citrus sp. | |
| Mg2+ | substrate MgATP | Cucurbita pepo | |
| Mg2+ | substrate MgATP | Hevea brasiliensis | |
| Mg2+ | substrate MgATP | Cucumis melo | |
| Mg2+ | substrate MgATP | Sarcophaga bullata | |
| Mg2+ | substrate MgATP | Pinus pinaster | |
| Mg2+ | substrate MgATP | Agave americana | |
| Mg2+ | substrate MgATP | Kalanchoe crenata | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 98000 | - |
gel filtration | Sus scrofa |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Agave americana | - |
- |
- |
| Citrus sp. | - |
orange | - |
| Cucumis melo | - |
- |
- |
| Cucurbita pepo | - |
pumpkin | - |
| Hevea brasiliensis | - |
rubber tree | - |
| Kalanchoe crenata | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
| Phaseolus vulgaris | - |
french bean | - |
| Pinus pinaster | - |
- |
- |
| Pinus radiata | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
| Sarcophaga bullata | - |
flesh fly | - |
| Staphylococcus aureus | - |
- |
- |
| Sus scrofa | - |
hog | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| ammonium sulfate, calcium phosphate gel, DEAE-cellulose, Sephadex G-200, DEAE-cellulose, Sephadex G-150 | Sus scrofa |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate | sequential mechanism | Sus scrofa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cotyledon | - |
Cucumis melo | - |
| cotyledon | etiolated | Phaseolus vulgaris | - |
| cotyledon | etiolated | Pinus pinaster | - |
| larva | - |
Sarcophaga bullata | - |
| latex | - |
Hevea brasiliensis | - |
| leaf | - |
Phaseolus vulgaris | - |
| leaf | - |
Pinus pinaster | - |
| leaf | - |
Agave americana | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Sus scrofa | - |
| liver | - |
Oryctolagus cuniculus | - |
| ovary | superovulated | Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 17.5 | - |
- |
Sus scrofa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + (R)-mevalonate | - |
Sus scrofa | ADP + (R)-5-phosphomevalonate | - |
? | |
| ATP + mevalonate | - |
Phaseolus vulgaris | ADP + phosphomevalonate | - |
? | |
| ATP + mevalonate | - |
Staphylococcus aureus | ADP + phosphomevalonate | - |
? | |
| ATP + mevalonate | - |
Rattus norvegicus | ADP + phosphomevalonate | - |
? | |
| ATP + mevalonate | - |
Saccharomyces cerevisiae | ADP + phosphomevalonate | - |
? | |
| ATP + mevalonate | - |
Oryctolagus cuniculus | ADP + phosphomevalonate | - |
? | |
| ATP + mevalonate | - |
Pinus radiata | ADP + phosphomevalonate | - |
? | |
| ATP + mevalonate | - |
Citrus sp. | ADP + phosphomevalonate | - |
? | |
| ATP + mevalonate | - |
Cucurbita pepo | ADP + phosphomevalonate | - |
? | |
| ATP + mevalonate | - |
Hevea brasiliensis | ADP + phosphomevalonate | - |
? | |
| ATP + mevalonate | - |
Cucumis melo | ADP + phosphomevalonate | - |
? | |
| ATP + mevalonate | - |
Sarcophaga bullata | ADP + phosphomevalonate | - |
? | |
| ATP + mevalonate | - |
Pinus pinaster | ADP + phosphomevalonate | - |
? | |
| ATP + mevalonate | - |
Agave americana | ADP + phosphomevalonate | - |
? | |
| ATP + mevalonate | - |
Kalanchoe crenata | ADP + phosphomevalonate | - |
? | |
| ATP + mevalonate | stereospecific reaction with R-mevalonate | Sus scrofa | ADP + phosphomevalonate | - |
? | |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Sus scrofa | isoelectric focusing | 4.8 | 4.7 |
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