Literature summary for 2.7.1.33 extracted from

Chiu, J.E.; Thekkiniath, J.; Mehta, S.; Mueller, C.; Bracher, F.; Ben Mamoun, C.
The yeast pantothenate kinase Cab1 is a master regulator of sterol metabolism and of susceptibility to ergosterol biosynthesis inhibitors (2019), J. Biol. Chem., 294, 14757-14767 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Saccharomyces cerevisiae	5829	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	required	Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + (R)-pantothenate	Saccharomyces cerevisiae	-	ADP + (R)-4'-phosphopantothenate	-	?
ATP + (R)-pantothenate	Saccharomyces cerevisiae ATCC 204508	-	ADP + (R)-4'-phosphopantothenate	-	?

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	Q04430	-	-
Saccharomyces cerevisiae ATCC 204508	Q04430	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + (R)-pantothenate	-	Saccharomyces cerevisiae	ADP + (R)-4'-phosphopantothenate	-	?
ATP + (R)-pantothenate	-	Saccharomyces cerevisiae ATCC 204508	ADP + (R)-4'-phosphopantothenate	-	?

Synonyms

Synonyms	Comment	Organism
Cab1	-	Saccharomyces cerevisiae
Cab1p	-	Saccharomyces cerevisiae

General Information

General Information	Comment	Organism
malfunction	altered pantothenate utilization dramatically alters the susceptibility of yeast cells to ergosterol biosynthesis inhibitors. Inhibition of pantothenic acid utilization synergizes with the activity of the ergosterol molecule-targeting antifungal amphotericin B and antagonizes that of the ergosterol pathway-targeting antifungal drug terbinafine. Inhibition of pantothenate utilization results in reduced susceptibility to terbinafine and enhanced susceptibility to amphotericin B. Inhibition of Cab1p activity results in reduced squalene and lanosterol levels	Saccharomyces cerevisiae
metabolism	detailed metabolic pathway from pantothenate to ergosterol involving enzyme Cab1, overview	Saccharomyces cerevisiae
physiological function	the pantothenate kinase Cab1p catalyzes the first step in the metabolism of pantothenic acid for CoA biosynthesis in budding yeast (Saccharomyces cerevisiae), it significantly regulates the levels of sterol intermediates and the activities of ergosterol biosynthesis-targeting antifungals. This regulation is mediated by changes both in the expression of ergosterol biosynthesis genes and in the levels of sterol intermediates. The CoA metabolism controls ergosterol biosynthesis and susceptibility to antifungals	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)