BRENDA - Enzyme Database show
show all sequences of 2.7.1.33

Modulation of pantothenate kinase 3 activity by small molecules that interact with the substrate/allosteric regulatory domain

Leonardi, R.; Zhang, Y.M.; Yun, M.K.; Zhou, R.; Zeng, F.Y.; Lin, W.; Cui, J.; Chen, T.; Rock, C.O.; White, S.W.; Jackowski, S.; Chem. Biol. 17, 892-902 (2010)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
cholesterol
about 125% activity at 0.1 mM
Homo sapiens
glyburide
; isoform PanK1b is activated by glyburide
Homo sapiens
additional information
isoform PanK3 is not activated by 1,4-naphthoquinone and phenylmercuric acid
Homo sapiens
O-oleoylcarnitine
140% activation at 0.1 mM
Homo sapiens
O-palmitoylcarnitine
120% activation at 0.1 mM
Homo sapiens
oleoylethanolamide
120% activation at 0.1 mM
Homo sapiens
tamoxifen
140% activation at 0.1 mM
Homo sapiens
Engineering
Amino acid exchange
Commentary
Organism
A267F
catalytically inactive
Homo sapiens
A269F
catalytically inactive
Homo sapiens
R207A
catalytically inactive
Homo sapiens
S195V
the mutant is insensitive to acetyl-CoA and has a KM defect for pantothenate
Homo sapiens
Inhibitors
Inhibitors
Commentary
Organism
Structure
1,4-phenylene-bis(1,2-ethanediyl)bis-isothiourea dihydrobromide
-
Homo sapiens
acetyl-CoA
complete inhibition of isoform PanK3 at 0.008 mM
Homo sapiens
ADP
competitive inhibitor of isoform PanK3 with respect to ATP1 and a mixed-type inhibitor with respect to pantothenate
Homo sapiens
chloranil
-
Homo sapiens
dehydroisoandrosterone
about 30% residual activity at 0.1 mM (isoform PanK3)
Homo sapiens
Dehydroisoandrosterone sulfate
; about 8% residual activity at 0.1 mM (isoform PanK3)
Homo sapiens
ephedrine hydrochloride
-
Homo sapiens
estradiol
about 80% residual activity at 0.1 mM (isoform PanK3)
Homo sapiens
Estradiol sulfate
about 90% residual activity at 0.1 mM (isoform PanK3)
Homo sapiens
Estrone sulfate
about 50% residual activity at 0.1 mM (isoform PanK3)
Homo sapiens
Fusidic acid
-
Homo sapiens
glipizide
-
Homo sapiens
glyburide
-
Homo sapiens
GW5074
-
Homo sapiens
Hexachlorophene
-
Homo sapiens
MCC-555
MCC-555 inhibits all three isoforms with a rank order of PanK3 > PanK2 > PanK1b; MCC-555 inhibits all three isoforms with a rank order of PanK3 > PanK2 > PanK1b
Homo sapiens
additional information
isoform PanK3 is not inhibited by estrone
Homo sapiens
pioglitazone hydrochloride
-
Homo sapiens
pregnenolone sulfate
; about 10% residual activity at 0.1 mM (isoform PanK3); about 92% residual activity at 0.1 mM (isoform PanK3)
Homo sapiens
Psi-rhodomyrtoxin
-
Homo sapiens
Reactive blue 2
-
Homo sapiens
Ro 41-0960
-
Homo sapiens
rosiglitazone
-
Homo sapiens
tamoxifen
-
Homo sapiens
tolfenamic acid
-
Homo sapiens
tyrphostin AG 528
-
Homo sapiens
tyrphostin AG 808
-
Homo sapiens
WIN 62577
-
Homo sapiens
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.014
-
(R)-pantothenate
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
0.311
-
ATP
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Homo sapiens
Q9H999
isoform PanK3
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
HepG2/C3A cell
;
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + (R)-pantothenate
-
722018
Homo sapiens
ADP + (R)-4'-phosphopantothenate
-
-
-
?
IC50 Value
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.0001
-
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
Fusidic acid
0.0004
-
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
1,4-phenylene-bis(1,2-ethanediyl)bis-isothiourea dihydrobromide
0.0007
-
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
WIN 62577
0.001
-
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
pioglitazone hydrochloride
0.0013
-
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
Reactive blue 2
0.0016
-
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
ephedrine hydrochloride
0.0016
-
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
Psi-rhodomyrtoxin
0.0017
-
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
rosiglitazone
0.0025
-
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
pregnenolone sulfate
0.003
-
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
tyrphostin AG 528
0.0035
-
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
Dehydroisoandrosterone sulfate
0.0039
-
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
Ro 41-0960
0.0052
-
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
glipizide
0.0059
-
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
chloranil
0.0068
-
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
glyburide
0.0088
-
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
Hexachlorophene
0.009
-
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
tyrphostin AG 808
0.0092
-
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
GW5074
0.0092
-
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
tolfenamic acid
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
cholesterol
about 125% activity at 0.1 mM
Homo sapiens
glyburide
isoform PanK1b is activated by glyburide
Homo sapiens
glyburide
-
Homo sapiens
additional information
isoform PanK3 is not activated by 1,4-naphthoquinone and phenylmercuric acid
Homo sapiens
O-oleoylcarnitine
140% activation at 0.1 mM
Homo sapiens
O-palmitoylcarnitine
120% activation at 0.1 mM
Homo sapiens
oleoylethanolamide
120% activation at 0.1 mM
Homo sapiens
tamoxifen
140% activation at 0.1 mM
Homo sapiens
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
A267F
catalytically inactive
Homo sapiens
A269F
catalytically inactive
Homo sapiens
R207A
catalytically inactive
Homo sapiens
S195V
the mutant is insensitive to acetyl-CoA and has a KM defect for pantothenate
Homo sapiens
IC50 Value (protein specific)
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.0001
-
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
Fusidic acid
0.0004
-
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
1,4-phenylene-bis(1,2-ethanediyl)bis-isothiourea dihydrobromide
0.0007
-
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
WIN 62577
0.001
-
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
pioglitazone hydrochloride
0.0013
-
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
Reactive blue 2
0.0016
-
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
ephedrine hydrochloride
0.0016
-
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
Psi-rhodomyrtoxin
0.0017
-
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
rosiglitazone
0.0025
-
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
pregnenolone sulfate
0.003
-
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
tyrphostin AG 528
0.0035
-
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
Dehydroisoandrosterone sulfate
0.0039
-
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
Ro 41-0960
0.0052
-
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
glipizide
0.0059
-
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
chloranil
0.0068
-
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
glyburide
0.0088
-
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
Hexachlorophene
0.009
-
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
tyrphostin AG 808
0.0092
-
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
GW5074
0.0092
-
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
tolfenamic acid
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
1,4-phenylene-bis(1,2-ethanediyl)bis-isothiourea dihydrobromide
-
Homo sapiens
acetyl-CoA
complete inhibition of isoform PanK3 at 0.008 mM
Homo sapiens
ADP
competitive inhibitor of isoform PanK3 with respect to ATP1 and a mixed-type inhibitor with respect to pantothenate
Homo sapiens
chloranil
-
Homo sapiens
dehydroisoandrosterone
about 30% residual activity at 0.1 mM (isoform PanK3)
Homo sapiens
Dehydroisoandrosterone sulfate
; about 8% residual activity at 0.1 mM (isoform PanK3)
Homo sapiens
ephedrine hydrochloride
-
Homo sapiens
estradiol
about 80% residual activity at 0.1 mM (isoform PanK3)
Homo sapiens
Estradiol sulfate
about 90% residual activity at 0.1 mM (isoform PanK3)
Homo sapiens
Estrone sulfate
about 50% residual activity at 0.1 mM (isoform PanK3)
Homo sapiens
Fusidic acid
-
Homo sapiens
glipizide
-
Homo sapiens
glyburide
-
Homo sapiens
GW5074
-
Homo sapiens
Hexachlorophene
-
Homo sapiens
MCC-555
MCC-555 inhibits all three isoforms with a rank order of PanK3 > PanK2 > PanK1b
Homo sapiens
additional information
isoform PanK3 is not inhibited by estrone
Homo sapiens
pioglitazone hydrochloride
-
Homo sapiens
pregnenolone sulfate
; about 10% residual activity at 0.1 mM (isoform PanK3); about 92% residual activity at 0.1 mM (isoform PanK3)
Homo sapiens
Psi-rhodomyrtoxin
-
Homo sapiens
Reactive blue 2
-
Homo sapiens
Ro 41-0960
-
Homo sapiens
rosiglitazone
-
Homo sapiens
tamoxifen
-
Homo sapiens
tolfenamic acid
-
Homo sapiens
tyrphostin AG 528
-
Homo sapiens
tyrphostin AG 808
-
Homo sapiens
WIN 62577
-
Homo sapiens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.014
-
(R)-pantothenate
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
0.311
-
ATP
isoform PanK3, at pH 7.5 and 37°C
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
HepG2/C3A cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + (R)-pantothenate
-
722018
Homo sapiens
ADP + (R)-4'-phosphopantothenate
-
-
-
?
General Information
General Information
Commentary
Organism
metabolism
pantothenate kinase catalyzes the rate-controlling step in coenzyme A biosynthesis; pantothenate kinase catalyzes the rate-controlling step in coenzyme A biosynthesis
Homo sapiens
General Information (protein specific)
General Information
Commentary
Organism
metabolism
pantothenate kinase catalyzes the rate-controlling step in coenzyme A biosynthesis
Homo sapiens
Other publictions for EC 2.7.1.33
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
738773
Ogata
Prokaryotic type III pantothen ...
Escherichia coli
J. Gen. Appl. Microbiol.
61
266-269
2016
-
-
1
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
737839
Awuah
Exploring structural motifs ne ...
Escherichia coli
Bioorg. Med. Chem.
22
3083-3090
2014
-
-
-
-
-
-
-
28
-
-
-
1
-
3
-
-
-
-
-
-
-
-
28
-
-
-
-
28
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
28
-
-
-
1
-
-
-
-
-
-
-
-
28
-
-
-
-
28
-
-
-
-
-
-
-
-
28
28
737966
Ogata
Role of prokaryotic type I and ...
Bacillus subtilis
Can. J. Microbiol.
60
297-305
2014
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
739613
Hughes
Structural characterization of ...
Klebsiella pneumoniae, Klebsiella pneumoniae 342, Staphylococcus aureus, Staphylococcus aureus MSSA476
Proteins
82
1542-1548
2014
-
-
2
2
-
-
-
-
-
-
-
4
-
7
-
-
2
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
-
4
-
-
-
2
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
738582
Bjoerkelid
Structural and biochemical cha ...
Mycobacterium tuberculosis
J. Biol. Chem.
288
18260-18270
2013
-
-
1
1
-
-
7
-
-
-
-
1
-
4
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
7
-
-
-
-
-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
739611
Li
Crystal structures of Klebsiel ...
Klebsiella pneumoniae, Klebsiella pneumoniae 342
Proteins
81
1466-1472
2013
-
-
1
1
-
-
-
-
-
-
-
2
-
5
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
722830
Venkatraman
Screening, identification, and ...
Mycobacterium tuberculosis
J. Biomol. Screen.
17
293-302
2012
-
-
1
-
-
-
6
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
7
-
-
1
-
-
-
-
7
6
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
727436
Ishibashi
A detailed biochemical charact ...
Thermococcus kodakarensis
Extremophiles
16
819-828
2012
-
-
1
-
-
-
3
-
-
-
-
1
-
4
-
-
1
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
-
-
-
1
-
-
-
1
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
721160
Chetnani
Location and conformation of p ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Acta Crystallogr. Sect. D
67
774-783
2011
-
-
1
1
-
-
-
-
-
-
-
-
-
6
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
704326
Takagi
Pantothenate kinase from the t ...
Picrophilus torridus
J. Bacteriol.
192
233-241
2010
-
-
1
-
-
-
-
2
1
2
1
-
-
7
-
-
1
-
-
-
1
-
1
1
1
1
-
2
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
2
1
2
1
-
-
-
-
1
-
-
1
-
1
1
1
1
-
2
1
1
-
-
-
-
-
-
-
-
722018
Leonardi
Modulation of pantothenate kin ...
Homo sapiens
Chem. Biol.
17
892-902
2010
7
-
-
-
4
-
28
2
-
-
-
-
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
19
8
-
-
-
-
4
-
19
29
-
2
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
1
2
-
-
-
722262
Gutierrez
Zinc accumulation in heterozyg ...
Drosophila melanogaster
FEBS Lett.
584
2942-2946
2010
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
722932
Mandakh
Identification and characteriz ...
Streptomyces peucetius, Streptomyces peucetius ATCC 27952
J. Microbiol. Biotechnol.
20
1689-1695
2010
-
-
1
-
-
-
-
-
-
-
2
-
-
6
-
-
1
-
-
-
-
-
2
1
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
-
-
2
1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
722968
Chetnani
M. tuberculosis pantothenate k ...
Mycobacterium tuberculosis
J. Mol. Biol.
400
171-185
2010
-
-
1
1
-
-
-
2
-
-
-
-
-
3
-
-
1
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
2
2
723121
Awasthy
Essentiality and functional an ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (ATCC 27294)
Microbiology
156
2691-2701
2010
-
-
1
-
-
-
-
-
-
-
-
-
-
9
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
723517
Leonardi
Pantothenate kinase 1 is requi ...
Mus musculus
PLoS ONE
5
e11107
2010
-
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
701469
Chetnani
Mycobacterium tuberculosis pan ...
Escherichia coli, Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Acta Crystallogr. Sect. D
65
312-325
2009
-
-
2
1
-
-
-
4
-
-
-
-
-
8
-
-
2
-
-
-
-
-
2
-
-
-
-
4
-
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
4
-
-
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
4
-
-
-
-
-
-
-
-
4
4
702284
Yao
Characterization and kinetics ...
Enterococcus faecalis
Biochemistry
48
2799-2806
2009
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
703325
Olzhausen
Genetic analysis of coenzyme A ...
Saccharomyces cerevisiae
Curr. Genet.
55
163-173
2009
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
703958
Wu
Pantothenate kinase-associated ...
Drosophila melanogaster, Homo sapiens
Hum. Mol. Genet.
18
3659-3672
2009
-
-
2
-
-
-
-
-
2
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
705271
Doi
Siblings with the adult-onset ...
Homo sapiens
J. Neurol. Sci.
290
172-176
2009
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
706042
Rowan
Nucleoside triphosphate mimicr ...
Bacillus anthracis
Org. Biomol. Chem.
7
4029-4036
2009
-
-
1
-
-
-
1
7
-
-
-
-
-
2
-
-
1
-
-
-
-
-
7
-
-
-
-
7
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
1
7
-
-
-
-
-
-
-
1
-
-
-
-
7
-
-
-
-
7
-
-
-
-
-
-
-
-
7
7
684736
Isaac
Pallidal stimulation for panto ...
Homo sapiens
Arch. Dis. Child.
93
239-240
2008
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
685199
Yang
Structural basis for substrate ...
Helicobacter pylori, Thermotoga maritima
Biochemistry
47
1369-1380
2008
-
-
2
1
-
-
-
-
-
-
-
-
-
4
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
686546
Mikati
Deep brain stimulation as a mo ...
Homo sapiens
Eur. J. Paediatr. Neurol.
13
61-64
2008
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
686816
Spry
Coenzyme A biosynthesis: an an ...
Escherichia coli, Mycobacterium tuberculosis, Staphylococcus aureus
FEMS Microbiol. Rev.
32
56-106
2008
-
-
2
2
-
-
2
3
-
-
-
1
-
4
-
-
2
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
2
-
3
-
-
-
1
-
-
-
2
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687016
Chan
Pantothenate kinase-associated ...
Homo sapiens
Hong Kong Med. J.
14
70-73
2008
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687036
Bosveld
De novo CoA biosynthesis is re ...
Drosophila sp. (in: Insecta)
Hum. Mol. Genet.
17
2058-2069
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687425
Paige
The type III pantothenate kina ...
Bacillus anthracis
J. Bacteriol.
190
6271-6275
2008
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688109
Ellers
Temperature-induced gene expre ...
Orchesella cincta
J. Exp. Zool. B Mol. Dev. Evol.
310
137-147
2008
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689108
Lyoo
Anticholinergic-responsive gai ...
Homo sapiens
Mov. Disord.
23
283-284
2008
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689193
McNeill
T2* and FSE MRI distinguishes ...
Homo sapiens
Neurology
70
1614-1619
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
690187
Marquez
Neuropathologic findings in an ...
Gorilla beringei
Vet. Pathol.
45
531-537
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672234
Nicely
Structure of the type III pant ...
Bacillus anthracis
Biochemistry
46
3234-3245
2007
-
-
1
1
-
-
1
-
-
-
-
1
-
6
-
-
1
-
-
-
-
-
2
1
-
-
-
-
-
-
-
1
-
-
-
-
-
2
1
2
-
-
-
1
-
-
-
-
-
1
-
-
-
2
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673027
Zhang
Chemical knockout of pantothen ...
Mus musculus
Chem. Biol.
14
291-302
2007
-
-
1
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674852
Lehane
Feedback inhibition of pantoth ...
Plasmodium falciparum
J. Biol. Chem.
282
25395-25405
2007
-
-
-
-
-
-
4
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
1
-
-
-
1
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676884
Leonardi
Activation of human mitochondr ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
104
1494-1499
2007
2
-
1
-
-
-
2
-
2
-
-
-
-
3
-
-
1
-
-
1
1
-
2
-
-
-
-
-
-
-
-
1
-
-
1
3
-
2
1
-
-
-
1
3
-
-
3
-
-
-
-
-
-
2
-
1
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
677979
Kumar
How pantothenol intervenes in ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Biochem. Biophys. Res. Commun.
361
903-909
2007
-
-
1
-
-
-
1
6
-
-
-
-
-
7
-
-
-
-
-
-
-
-
4
-
-
-
-
6
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
1
6
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
684227
Clement
Neurodegeneration with brain i ...
Homo sapiens
Acta Neurol. Belg.
107
26-31
2007
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
686741
Leonardi
Localization and regulation of ...
Homo sapiens, Mus musculus
FEBS Lett.
581
4639-4644
2007
2
-
1
-
-
-
2
-
2
-
-
-
-
5
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
2
2
-
1
-
-
-
-
2
2
-
-
2
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687612
Hong
Crystal structures of human pa ...
Homo sapiens
J. Biol. Chem.
282
27984-27993
2007
-
-
1
1
-
-
1
-
-
-
-
2
-
3
-
-
1
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
2
-
-
-
-
-
2
-
-
-
2
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687943
Kazek
A novel PANK2 gene mutation: c ...
Homo sapiens
J. Child Neurol.
22
1256-1259
2007
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688176
Kuo
Deprivation of pantothenic aci ...
Mus musculus
J. Inherit. Metab. Dis.
30
310-317
2007
-
1
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688202
Freeman
Intellectual and adaptive beha ...
Homo sapiens
J. Intellect. Disabil. Res.
51
417-426
2007
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689010
Wilfred
Energizing miRNA research: a r ...
Homo sapiens
Mol. Genet. Metab.
91
209-217
2007
-
-
-
-
-
-
-
-
-
-
-
1
-
4
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689128
Schneider
The Huntingtons disease-like s ...
Homo sapiens
Nat. Clin. Pract. Neurol.
3
517-525
2007
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689334
Saleheen
Novel mutation in the PANK2 ge ...
Homo sapiens
Pediatr. Neurol.
37
296-298
2007
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689335
Shields
Pallidal stimulation for dysto ...
Homo sapiens
Pediatr. Neurol.
37
442-445
2007
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
690019
Wong
Iron toxicity as a potential f ...
Homo sapiens
Retina (Philadelphia, Pa. )
27
997-1003
2007
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
661331
Virga
Structure-activity relationshi ...
Aspergillus nidulans, Escherichia coli, Mus musculus, Staphylococcus aureus
Bioorg. Med. Chem.
14
1007-1020
2006
-
-
-
-
-
-
108
-
-
4
-
4
-
8
-
-
-
-
-
-
-
-
8
-
4
-
-
-
4
-
-
4
-
-
-
-
-
-
4
-
-
-
-
108
-
-
-
4
-
4
-
-
-
-
-
-
-
-
8
-
4
-
-
-
4
-
-
-
-
-
-
-
-
-
662455
Zhang
Biochemical properties of huma ...
Homo sapiens
J. Biol. Chem.
281
107-114
2006
-
-
1
-
14
-
2
5
-
1
-
1
-
2
-
-
-
-
-
1
-
-
2
1
1
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
14
-
-
2
-
5
-
1
-
1
-
-
-
-
-
1
-
-
2
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
671053
Das
Invariance and variability in ...
Escherichia coli, Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Acta Crystallogr. Sect. D
62
628-638
2006
-
-
1
1
-
-
2
-
-
-
1
-
-
8
-
-
1
-
-
-
-
-
2
1
-
-
-
-
-
-
-
2
-
-
-
-
-
1
2
1
-
-
-
2
-
-
-
-
1
-
-
-
-
1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671347
Hartig
Genotypic and phenotypic spect ...
Homo sapiens
Ann. Neurol.
59
248-256
2006
-
-
1
-
2
-
-
-
1
-
1
-
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
2
-
-
-
-
-
1
-
1
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671767
Chen
Analysis of the temperature-se ...
Escherichia coli
Biochem. Biophys. Res. Commun.
345
834-842
2006
-
-
-
-
3
-
-
-
-
-
2
-
-
2
-
-
1
-
-
-
-
-
1
-
-
1
1
-
-
-
-
1
-
-
-
-
-
-
1
-
3
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
674291
Yang
Crystal structure of a type II ...
Thermotoga maritima
J. Bacteriol.
188
5532-5540
2006
-
-
1
1
6
-
1
2
-
-
-
-
-
7
-
-
1
-
-
-
-
-
1
2
-
-
-
1
-
-
-
1
-
-
-
-
-
1
1
1
6
-
-
1
-
2
-
-
-
-
-
-
-
1
-
-
-
-
1
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
676548
Tilton
Plant coenzyme A biosynthesis: ...
Arabidopsis thaliana
Plant Mol. Biol.
61
629-642
2006
-
-
-
-
-
-
-
-
1
-
1
-
-
6
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
677154
Hong
Prokaryotic type II and type I ...
Pseudomonas aeruginosa, Staphylococcus aureus
Structure
14
1251-1261
2006
-
-
2
2
13
-
-
-
-
8
-
-
-
4
-
-
2
-
-
-
-
-
2
2
-
-
-
-
-
-
-
2
-
-
-
-
-
2
2
2
13
-
-
-
-
-
-
8
-
-
-
-
-
2
-
-
-
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
660631
Das
Expression, purification, crys ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Acta Crystallogr. Sect. F
F61
65-67
2005
-
-
1
1
-
-
-
-
-
-
1
2
-
161
-
-
1
-
-
-
-
-
4
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
1
-
-
-
-
-
-
-
-
1
2
-
-
-
1
-
-
-
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
660726
Spry
A class of pantothenic acid an ...
Homo sapiens, Plasmodium falciparum
Antimicrob. Agents Chemother.
49
4649-4657
2005
-
-
-
-
-
-
14
-
-
2
-
2
-
4
-
-
-
-
-
2
-
-
4
-
2
-
-
-
-
-
-
2
13
-
-
-
-
-
2
-
-
-
-
14
13
-
-
2
-
2
-
-
-
-
-
2
-
-
4
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
662369
Brand
Characterization of a new pant ...
Bacillus subtilis, Helicobacter pylori
J. Biol. Chem.
280
20185-20188
2005
2
-
2
-
-
-
2
4
-
4
-
2
-
7
-
-
2
-
-
-
-
-
8
-
2
-
-
4
2
-
-
4
-
-
-
2
-
2
4
-
-
-
-
2
-
4
-
4
-
2
-
-
-
2
-
-
-
-
8
-
2
-
-
4
2
-
-
-
-
-
-
-
-
-
662406
Zhang
Feedback regulation of murine ...
Mus musculus
J. Biol. Chem.
280
32594-32601
2005
-
-
1
-
1
-
5
4
-
1
2
1
-
2
-
-
-
-
-
1
-
-
2
1
1
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
1
-
-
5
-
4
-
1
2
1
-
-
-
-
-
1
-
-
2
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
662408
Leonardi
A pantothenate kinase from Sta ...
Staphylococcus aureus, Staphylococcus aureus RN4220
J. Biol. Chem.
280
3314-3322
2005
1
-
1
-
-
-
3
4
2
1
2
4
-
24
-
-
1
-
-
-
1
-
10
1
1
-
-
4
1
-
-
1
-
-
2
1
-
1
1
-
-
-
2
3
-
4
2
1
2
4
-
-
-
1
-
-
1
-
10
1
1
-
-
4
1
-
-
-
-
-
-
-
-
-
662687
Kotzbauer
Altered neuronal mitochondrial ...
Homo sapiens
J. Neurosci.
25
689-698
2005
-
-
1
-
7
-
1
-
3
-
2
2
-
2
-
1
1
-
-
4
-
-
3
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
7
-
-
1
-
-
3
-
2
2
-
-
1
1
-
4
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675942
Li
High glucose upregulates panto ...
Rattus norvegicus
Mol. Cell. Biochem.
277
117-125
2005
-
-
1
-
-
-
-
-
1
-
-
-
-
5
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
660712
Johnson
Mitochondrial localization of ...
Homo sapiens
Ann. N. Y. Acad. Sci.
1012
282-298
2004
-
-
1
-
1
-
-
-
2
-
-
2
-
2
-
-
1
-
-
2
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
-
2
-
-
2
-
-
-
1
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
662251
Ivey
The structure of the pantothen ...
Escherichia coli
J. Biol. Chem.
279
35622-35629
2004
-
-
1
1
-
-
4
3
-
1
-
1
-
3
-
-
1
1
-
-
-
-
6
1
1
-
-
-
1
-
-
1
-
-
-
-
-
1
1
1
-
-
-
4
-
3
-
1
-
1
-
-
-
1
-
-
-
-
6
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
641398
Choudhry
Inhibitors of pantothenate kin ...
Staphylococcus aureus
Antimicrob. Agents Chemother.
47
2051-2055
2003
-
-
-
-
-
-
1
2
-
-
1
-
-
2
-
-
1
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
1
-
2
-
-
1
-
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641399
Rock
Role of feedback regulation of ...
Escherichia coli
J. Bacteriol.
185
3410-3415
2003
-
-
-
-
3
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641400
Rock
The murine pantothenate kinase ...
Mus musculus
Gene
291
35-43
2002
-
-
1
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641401
Afshar
Fumble encodes a pantothenate ...
Drosophila melanogaster
Genetics
157
1267-1276
2001
-
-
1
-
-
-
-
-
1
-
2
-
-
6
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641396
Yun
Structural basis for the feedb ...
Escherichia coli
J. Biol. Chem.
275
28093-28099
2000
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641397
Rock
Pantothenate kinase regulation ...
Mus musculus
J. Biol. Chem.
275
1377-1383
2000
1
-
-
-
-
-
1
-
-
-
-
-
-
4
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641402
Calder
Cloning and characterization o ...
Aspergillus nidulans
J. Biol. Chem.
274
2014-2020
1999
-
-
1
-
-
-
1
-
-
-
1
-
-
5
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641388
Falk
Coenzyme A biosynthesis in pla ...
Brassica napus, Spinacia oleracea
Arch. Biochem. Biophys.
301
424-430
1993
1
-
-
-
-
-
9
2
1
2
-
2
-
4
-
-
1
-
-
3
1
1
4
-
-
-
-
-
1
1
-
-
-
-
-
1
-
-
-
-
-
-
-
9
-
2
1
2
-
2
-
-
-
1
-
3
1
1
4
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
641393
Vallari
Regulation of pantothenate kin ...
Escherichia coli
J. Biol. Chem.
262
2468-2471
1987
1
-
-
-
-
-
11
2
1
1
-
1
-
2
-
-
1
-
-
-
-
1
4
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
11
-
2
1
1
-
1
-
-
-
1
-
-
-
1
4
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
641394
Halvorsen
-
Multiple molecular forms of ra ...
Rattus norvegicus
Scand. J. Clin. Lab. Invest.
46
67-70
1986
-
-
-
-
-
-
2
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
641391
Fisher
The properties and regulation ...
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
J. Biol. Chem.
260
15745-15751
1985
-
-
-
-
-
2
9
2
-
2
-
2
-
163
-
-
-
-
-
2
1
1
4
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
2
-
9
-
2
-
2
-
2
-
-
-
-
-
2
1
1
4
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
641392
Fisher
Regulation of pantothenate kin ...
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
FEBS Lett.
190
293-296
1985
1
-
-
-
-
-
1
-
1
1
-
-
-
163
-
-
-
-
-
5
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
1
1
-
-
-
-
-
-
-
5
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4412
Nishimura
-
Mechanism of coenzyme A biosyn ...
Micrococcus luteus
J. Ferment. Technol.
61
95-99
1983
-
-
-
-
-
-
-
-
1
1
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641390
Halvorsen
Regulation of the biosynthesis ...
Rattus norvegicus
Eur. J. Biochem.
124
211-215
1982
-
-
-
-
-
-
10
1
2
1
-
-
-
3
-
-
-
-
-
2
1
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
10
-
1
2
1
-
-
-
-
-
-
-
2
1
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
641389
Shimizu
-
Purification and properties of ...
Corynebacterium ammoniagenes
Agric. Biol. Chem.
37
2863-2870
1973
-
-
-
-
-
1
19
3
-
6
1
-
-
1
-
-
1
-
-
-
1
1
7
-
1
-
3
-
1
-
4
-
4
-
-
-
-
-
-
-
-
1
-
19
4
3
-
6
1
-
-
-
-
1
-
-
1
1
7
-
1
-
3
-
1
-
4
-
-
-
-
-
-
-
641387
Abiko
Purification and properties of ...
Rattus norvegicus
Biochim. Biophys. Acta
268
364-372
1972
-
-
-
-
-
2
6
2
1
1
-
1
-
2
-
-
-
-
-
2
1
2
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
2
-
6
-
2
1
1
-
1
-
-
-
-
-
2
1
2
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
4406
Brown
The metabolism of pantothenic ...
Escherichia coli, Lactobacillus plantarum, Morganella morganii, no activity in Lactobacillus helveticus, no activity in Neurospora crassa, Rattus norvegicus, Saccharomyces cerevisiae
J. Biol. Chem.
234
370-378
1959
-
-
-
-
-
-
-
-
5
5
-
5
-
7
-
-
2
-
-
2
-
-
10
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
5
-
5
-
-
-
2
-
2
-
-
10
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-