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BRENDA support

Literature summary for 2.7.1.3 extracted from

  • Parks, R.E.; Ben-Gershom, E.; Lardy, H.E.
    Liver fructokinase (1957), J. Biol. Chem., 227, 231-242.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
ADP strong, noncompetitive Bos taurus
ATP
-
Bos taurus

Metals/Ions

Metals/Ions Comment Organism Structure
Cs+ absolute requirement for both monovalent and divalent cations, when Mg2+ fills the requirement for divalent cation, K+ and Rb+ are the most active monovalent cations, NH4+, Na+, Cs+ and Li+ are decreasingly active Bos taurus
K+ absolute requirement for both monovalent and divalent cations, when Mg2+ fills the requirement for divalent cation, K+ and Rb+ are the most active monovalent cations Bos taurus
K+ NH4+, Na+, Cs+ and Li+ are decreasingly active Bos taurus
Li+ absolute requirement for both monovalent and divalent cations, when Mg2+ fills the requirement for divalent cation, K+ and Rb+ are the most active monovalent cations, NH4+, Na+, Cs+ and Li+ are decreasingly active Bos taurus
Mg2+ absolute requirement for both monovalent and divalent cations, for optimal activity the concentration of Mg2+ must equal or exceed the concentration of ATP Bos taurus
Na+ absolute requirement for both monovalent and divalent cations, when Mg2+ fills the requirement for divalent cation, K+ and Rb+ are the most active monovalent cations, NH4+, Na+, Cs+ and Li+ are decreasingly active Bos taurus
NH4+ absolute requirement for both monovalent and divalent cations, when Mg2+ fills the requirement for divalent cation, K+ and Rb+ are the most active monovalent cations, NH4+, Na+, Cs+ and Li+ are decreasingly active Bos taurus
Rb+ absolute requirement for both monovalent and divalent cations, when Mg2+ fills the requirement for divalent cation, K+ and Rb+ are the most active monovalent cations, NH4+, Na+, Cs+ and Li+ are decreasingly active Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + D-fructose Bos taurus D-fructose metabolism ADP + D-fructose 1-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + D-fructose
-
Bos taurus ADP + D-fructose 1-phosphate
-
?
ATP + D-fructose D-fructose metabolism Bos taurus ADP + D-fructose 1-phosphate
-
?
additional information not: UTP Bos taurus ?
-
?
additional information not: ITP Bos taurus ?
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5 7.8
-
Bos taurus