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Literature summary for 2.7.1.27 extracted from
- Purification and properties of erythritol kinase from Propionibacterium pentosaceum (1961), J. Biol. Chem., 236, 2581-2584.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | optimal Mg2+/ATP ratio for activation: 2/1, inhibition at ratios of 5/1 and 1/1 | Acidipropionibacterium acidipropionici |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.876 | - |
erythritol | pH 8.6, 28°C | Acidipropionibacterium acidipropionici | |
| 4.8 | - |
ATP | pH 8.6, 28°C | Acidipropionibacterium acidipropionici | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | 19% as effective as Mg2+ | Acidipropionibacterium acidipropionici | |
| Mg2+ | optimal Mg2+/ATP ratio: 2/1, 15% and 11% inhibition at ratios of 5/1 and 1/1, respectively | Acidipropionibacterium acidipropionici | |
| Mn2+ | 57% as effective as Mg2+ | Acidipropionibacterium acidipropionici | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + erythritol | Acidipropionibacterium acidipropionici | first step in erythritol metabolism | ADP + L-erythritol 1-phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Acidipropionibacterium acidipropionici | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| streptomycin, calcium phosphate gel, ammonium sulfate | Acidipropionibacterium acidipropionici |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.51 | - |
- |
Acidipropionibacterium acidipropionici |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 3°C, 1 mg/ml bovine serum albumin, at least 1 month, no loss of activity | Acidipropionibacterium acidipropionici |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + erythritol | - |
Acidipropionibacterium acidipropionici | ADP + L-erythritol 1-phosphate | - |
? | |
| ATP + erythritol | first step in erythritol metabolism | Acidipropionibacterium acidipropionici | ADP + L-erythritol 1-phosphate | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 28 | - |
assay at | Acidipropionibacterium acidipropionici |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.6 | - |
- |
Acidipropionibacterium acidipropionici |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6 | 9 | approx. 55% of maximal activity at pH 6.0, approx. 80% of maximal activity at pH 9.0 | Acidipropionibacterium acidipropionici |
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