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Literature summary for 2.7.1.25 extracted from

  • Xu, Z.H.; Thomae, B.A.; Eckloff, B.W.; Wieben, E.D.; Weinshilboum, R.M.
    Pharmacogenetics of human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPSS1): gene resequencing, sequence variation, and functional genomics (2003), Biochem. Pharmacol., 65, 1787-1796.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in COS-1 and HEK293 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
E531Q identified as naturally occurring mutation, E531Q found in a single sample of an African-American’s subject, almost no effect of mutations when expressed in COS-1 or HEK293 cells Homo sapiens
R333C identified as naturally occurring mutation, R333C found exclusively in Caucasian-American’s DNA, almost no effect of mutations when expressed in COS-1 or HEK293 cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + adenosine 5'-phosphosulfate Homo sapiens involved in the synthesis of the important sulfate donor 3'-phosphoadenosine 5'-phosphosulfate from ATP and sulfate, inactivating mutations of PAPSS2 causes skeletal disorders ADP + 3'-phosphoadenosine 5'-phosphosulfate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens O43252 PAPSS1; Caucasian-American and African-American subjects
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Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + adenosine 5'-phosphosulfate
-
Homo sapiens ADP + 3'-phosphoadenosine 5'-phosphosulfate
-
?
ATP + adenosine 5'-phosphosulfate involved in the synthesis of the important sulfate donor 3'-phosphoadenosine 5'-phosphosulfate from ATP and sulfate, inactivating mutations of PAPSS2 causes skeletal disorders Homo sapiens ADP + 3'-phosphoadenosine 5'-phosphosulfate
-
?

Synonyms

Synonyms Comment Organism
PAPSS PAPS synthetase, two isoforms: PAPSS1 and PAPSS2 Homo sapiens