Cloned (Comment) | Organism |
---|---|
expressed in COS-1 and HEK293 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
E531Q | identified as naturally occurring mutation, E531Q found in a single sample of an African-Americans subject, almost no effect of mutations when expressed in COS-1 or HEK293 cells | Homo sapiens |
R333C | identified as naturally occurring mutation, R333C found exclusively in Caucasian-Americans DNA, almost no effect of mutations when expressed in COS-1 or HEK293 cells | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + adenosine 5'-phosphosulfate | Homo sapiens | involved in the synthesis of the important sulfate donor 3'-phosphoadenosine 5'-phosphosulfate from ATP and sulfate, inactivating mutations of PAPSS2 causes skeletal disorders | ADP + 3'-phosphoadenosine 5'-phosphosulfate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O43252 | PAPSS1; Caucasian-American and African-American subjects | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + adenosine 5'-phosphosulfate | - |
Homo sapiens | ADP + 3'-phosphoadenosine 5'-phosphosulfate | - |
? | |
ATP + adenosine 5'-phosphosulfate | involved in the synthesis of the important sulfate donor 3'-phosphoadenosine 5'-phosphosulfate from ATP and sulfate, inactivating mutations of PAPSS2 causes skeletal disorders | Homo sapiens | ADP + 3'-phosphoadenosine 5'-phosphosulfate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PAPSS | PAPS synthetase, two isoforms: PAPSS1 and PAPSS2 | Homo sapiens |