Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.25 extracted from

  • Fuda, H.; Shimizu, C.; Lee, Y.C.; Akita, H.; Strott, C.A.
    Characterization and expression of human bifunctional 3'-phosphoadenosine 5'-phosphosulphate synthase isoforms (2002), Biochem. J., 365, 497-504.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.25

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.08
-
 ATP pH 8.0, 37°C, PAPSS 1 Homo sapiens
0.36
-
 ATP pH 8.0, 37°C, PAPSS 2b Homo sapiens
0.38
-
 ATP pH 8.0, 37°C, PAPSS 2a Homo sapiens

Organism

Organism UniProt Comment Textmining
Cavia porcellus O54820 guinea pig
-
Homo sapiens
-
 isoforms PAPSS 1, PAPSS 2a and 2b
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland PAPSS 1, 2a and 2b Homo sapiens
-
bone marrow PAPSS 1 Homo sapiens
-
brain PAPSS 1 Homo sapiens
-
cartilage PAPSS 1 is the predominant isoform in adults Homo sapiens
-
cartilage PAPSS 1 is the predominant isoform in adults Cavia porcellus
-
colon PAPSS 1, 2a and 2b Homo sapiens
-
kidney PAPSS 1, 2a and 2b Homo sapiens
-
liver PAPSS 1, 2a and 2b Homo sapiens
-
lung PAPSS 1, 2a and 2b Homo sapiens
-
ovary PAPSS 1, 2a and 2b Homo sapiens
-
placenta PAPSS 1, 2a and 2b Homo sapiens
-
prostate PAPSS 1 Homo sapiens
-
small intestine PAPSS 1, 2a and 2b Homo sapiens
-
spleen PAPSS 1, 2a and 2b Homo sapiens
-
stomach PAPSS 1 Homo sapiens
-
thymus PAPSS 1 Homo sapiens
-
thyroid gland PAPSS 1, 2a and 2b Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + adenosine 5-phosphosulfate i.e. adenylylsulfate or APS Homo sapiens ADP + 3'-phosphoadenosine 5'-phosphosulfate i.e. 3'-phosphoadenylylsulfate or PAPS, via a phosphorylated enzyme intermediate ?
ATP + adenosine 5-phosphosulfate i.e. adenylylsulfate or APS Cavia porcellus ADP + 3'-phosphoadenosine 5'-phosphosulfate i.e. 3'-phosphoadenylylsulfate or PAPS, via a phosphorylated enzyme intermediate ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.7
-
 ATP pH 8.0, 37°C, PAPSS 1 Homo sapiens
2.3
-
 ATP pH 8.0, 37°C, PAPSS 2a Homo sapiens
4.4
-
 ATP pH 8.0, 37°C, PAPSS 2b Homo sapiens