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Literature summary for 2.7.1.24 extracted from

  • Wang, T.P.; Kaplan, N.O.
    Kinases for the synthesis of coenzyme A and triphosphopyridine nucleotide (1954), J. Biol. Chem., 206, 311-325.
    View publication on PubMed
Search for more literature for 2.7.1.24

Activating Compound

Activating Compound Comment Organism Structure
cysteine activation Anas platyrhynchos
cysteine activation Columba sp.
cysteine requirement Anas platyrhynchos
cysteine requirement Columba sp.

General Stability

General Stability Organism
stable to repeated freeze-thawing cycles Columba sp.

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition by F- with or without phosphate, adenosine, 2-, 3- or 5-adenylic acids, ADP, NAD+, NADH, deamino-NAD+, adenosine diphosphate ribose Columba sp.

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.003
-
 dephospho-CoA pH 8.2, 37°C Columba sp.

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Anas platyrhynchos 5739
-
mitochondrion
-
 Columba sp. 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ requirement Anas platyrhynchos
Mg2+ requirement Columba sp.

Organism

Organism UniProt Comment Textmining
Anas platyrhynchos
-
 duck
-
Columba sp.
-
-
-

Purification (Commentary)

Purification (Comment) Organism
4.5fold from liver acetone powder Columba sp.

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Anas platyrhynchos
-
liver
-
 Columba sp.
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Columba sp.

Storage Stability

Storage Stability Organism
-15°C, partially purified preparation, at least 2 months Columba sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + dephospho-CoA specific Anas platyrhynchos ADP + CoA
-
 ?
ATP + dephospho-CoA specific Columba sp. ADP + CoA
-
 ?
ATP + dephospho-CoA ITP or ADP are no substrates Anas platyrhynchos ADP + CoA
-
 ?
ATP + dephospho-CoA ITP or ADP are no substrates Columba sp. ADP + CoA
-
 ?
additional information assay method: arsenolysis of dephospho-CoA, formation of CoA Anas platyrhynchos ?
-
 ?
additional information assay method: arsenolysis of dephospho-CoA, formation of CoA Columba sp. ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Anas platyrhynchos
37
-
 assay at Columba sp.

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.2
-
 assay at Columba sp.

Cofactor

Cofactor Comment Organism Structure
ATP requirement Anas platyrhynchos
ATP requirement Columba sp.