Literature summary for 2.7.1.23 extracted from

Hoxhaj, G.; Ben-Sahra, I.; Lockwood, S.E.; Timson, R.C.; Byles, V.; Henning, G.T.; Gao, P.; Selfors, L.M.; Asara, J.M.; Manning, B.D.
Direct stimulation of NADP+ synthesis through Akt-mediated phosphorylation of NAD kinase (2019), Science, 363, 1088-1092 .

Search for more literature for 2.7.1.23

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Homo sapiens	5829	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + NAD+	Homo sapiens	NAD+ kinase is the sole cytosolic enzyme that catalyzes the synthesis of NADP+ from NAD+	ADP + NADP+	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O95544	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	Akt-mediated phosphorylation of NAD+ kinase stimulates its activity to increase NADP+ production through relief of an autoinhibitory function inherent to its amino terminus. NAD+ kinase (isoform 3) lacking this regulatory region exhibits constitutively increased activity	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEK-293 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + NAD+	-	Homo sapiens	ADP + NADP+	-	?
ATP + NAD+	NAD+ kinase is the sole cytosolic enzyme that catalyzes the synthesis of NADP+ from NAD+	Homo sapiens	ADP + NADP+	-	?

Synonyms

Synonyms	Comment	Organism
NADK	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)