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Literature summary for 2.7.1.23 extracted from

  • Grose, J.H.; Joss, L.; Velick, S.F.; Roth, J.R.
    Evidence that feedback inhibition of NAD kinase controls responses to oxidative stress (2006), Proc. Natl. Acad. Sci. USA, 103, 7601-7606.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.23

Inhibitors

Inhibitors Comment Organism Structure
NADH allosterically inhibited Salmonella enterica
NADPH allosterically inhibited Salmonella enterica

Organism

Organism UniProt Comment Textmining
Salmonella enterica
-
-
-

Subunits

Subunits Comment Organism
dimer without effectors, NadK exists as an equilibrium mixture of dimers and tetramers but is converted entirely to tetramers in the presence of the inhibitor NADPH. Comparison of NadK kinetic parameters with pool sizes of NADH and NADPH suggests that NadK is substantially inhibited during normal growth and, thus, can increase its activity greatly in response to temporary drops in the pools of inhibitory NADH and NADPH. The primary inhibitor is NADPH during aerobic growth and NADH during anaerobic growth Salmonella enterica
tetramer without effectors, NadK exists as an equilibrium mixture of dimers and tetramers but is converted entirely to tetramers in the presence of the inhibitor NADPH. Comparison of NadK kinetic parameters with pool sizes of NADH and NADPH suggests that NadK is substantially inhibited during normal growth and, thus, can increase its activity greatly in response to temporary drops in the pools of inhibitory NADH and NADPH. The primary inhibitor is NADPH during aerobic growth and NADH during anaerobic growth Salmonella enterica

Synonyms

Synonyms Comment Organism
NADK
-
 Salmonella enterica