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Literature summary for 2.7.1.228 extracted from

  • Dickson, R.; Nagiec, E.; Wells, G.; Nagiec, M.; Lester, R.
    Synthesis of mannose-(inositol-P)2-ceramide, the major sphingolipid in Saccharomyces cerevisiae, requires the IPT1 (YDR072c) gene (1997), J. Biol. Chem., 272, 29620-29625 .
    View publication on PubMed
Search for more literature for 2.7.1.228

Inhibitors

Inhibitors Comment Organism Structure
auaA
-
 Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-phosphatidyl-1D-myo-inositol + a very-long-chain mannosylinositol phospho-(2'R)-2'-hydroxyphytoceramide Saccharomyces cerevisiae
-
 1,2-diacyl-sn-glycerol + a very-long-chain mannosyl-diphosphoinositol-(2'R)-2'-hydroxyphytoceramide
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P38954
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol + a very-long-chain mannosylinositol phospho-(2'R)-2'-hydroxyphytoceramide
-
 Saccharomyces cerevisiae 1,2-diacyl-sn-glycerol + a very-long-chain mannosyl-diphosphoinositol-(2'R)-2'-hydroxyphytoceramide
-
 ?

Synonyms

Synonyms Comment Organism
IPT1
-
 Saccharomyces cerevisiae
YDR072c
-
 Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function Ipt1 (inositolphosphotransferase 1) is required for synthesis of mannose-(inositol-P)2-ceramide. An Ipt1-deletion strain fails to accumulate mannose-(inositol-P)2-ceramide and instead accumulates increased amounts of the precursor mannose-inositol-P-ceramide. The mutant also fails to incorporate radioactive precursors into mannose-(inositol-P)2-ceramide, and membranes prepared from it do not incorporate [3H-inositol]phosphatidylinositol into mannose-(inositol-P)2-ceramide. An Ipt1-deletion mutant has no severe phenotypic effects but is slightly more resistant to growth inhibition by calcium ions Saccharomyces cerevisiae