Cloned (Comment) | Organism |
---|---|
gene Nmrk2, quantitative RT-PCR enzyme expression analysis | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of H6PDKO/NRK2 double KO mice. H6PDKO/NRK2 double KO mice do not display an exaggerated timing or severity of myopathy or overt change in mitochondrial metabolism despite depression of NAD+ availability. Metabolome analysis | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
sarcoplasmic reticulum | - |
Mus musculus | 16529 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-(beta-D-ribofuranosyl)-nicotinamide | Mus musculus | - |
ADP + beta-nicotinamide D-ribonucleotide | - |
? | |
ATP + 1-(beta-D-ribofuranosyl)-nicotinamide | Mus musculus C57/BL6J | - |
ADP + beta-nicotinamide D-ribonucleotide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q9D7C9 | - |
- |
Mus musculus C57/BL6J | Q9D7C9 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cardiac muscle fiber | - |
Mus musculus | - |
skeletal muscle | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-(beta-D-ribofuranosyl)-nicotinamide | - |
Mus musculus | ADP + beta-nicotinamide D-ribonucleotide | - |
? | |
ATP + 1-(beta-D-ribofuranosyl)-nicotinamide | - |
Mus musculus C57/BL6J | ADP + beta-nicotinamide D-ribonucleotide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
nicotinamide riboside kinase | - |
Mus musculus |
nicotinamide riboside kinase 2 | - |
Mus musculus |
NMRK2 | - |
Mus musculus |
Nrk2 | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | nicotinamide riboside kinase 2 (NRK2) expression is decreased in wild-type muscle | down |
Mus musculus | depression of NAD+ availability leads to activation of NRK2. In cardiomyocytes, the NRK2 gene is activated by energy stress and NAD+ depletion through AMP-activated protein kinase and peroxisome proliferator-activated receptor alpha dependant mechanisms | up |
General Information | Comment | Organism |
---|---|---|
malfunction | nicotinamide riboside kinase 2 (NRK2) deficiency alone has minimal impact in wild-type mice | Mus musculus |
malfunction | induction of the nicotinamide riboside kinase NAD+ salvage pathway in a model of sarcoplasmic reticulum dysfunction. hexose-6-phosphate dehydrogenase (H6PD)-KO skeletal muscle shows adaptations in the routes regulating nicotinamide and NAD+ biosynthesis, with significant activation of the nicotinamide riboside kinase 2 (NRK2) pathway. Associated with changes in NAD+ biosynthesis, H6PD-KO muscle has impaired mitochondrial respiratory capacity with altered mitochondrial acylcarnitine and acetyl-CoA metabolism. Boosting NAD+ levels through the NRK2 pathway using the precursor nicotinamide riboside elevated NAD+/NADH but has no effect to mitigate endoplasmic reticulum stress and dysfunctional mitochondrial respiratory capacity or acetyl-CoA metabolism. Similarly, H6PD-KO/NRK2 double KO mice do not display an exaggerated timing or severity of myopathy or overt change in mitochondrial metabolism despite depression of NAD+ availability. H6PDKO/NRK2 double KO mice do not display an exaggerated timing or severity of myopathy or overt change in mitochondrial metabolism despite depression of NAD+ availability. Alterations in nicotinamide metabolism in H6PD-KO muscle, overview. Upregulation of NRK2 may be an early adaptive response to metabolic stress and the need to defend NAD+ availability | Mus musculus |
metabolism | metabolome analysis. Upregulation of NRK2 may be an early adaptive response to metabolic stress and the need to defend NAD+ availability | Mus musculus |
physiological function | upregulation of nicotinamide riboside kinase 2 (NRK2) mediated salvage of nicotinamide riboside into NAD+ is an early adaptation to perturbed muscle sarcoplasmic reticulum NAD(P)(H) homeostasis and impaired mitochondrial energy production in hexose-6-posphate dehydrogenase deficiency | Mus musculus |
physiological function | NRK2 is dispensable in H6PD-KO myopathy | Mus musculus |