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Literature summary for 2.7.1.22 extracted from

  • Fletcher, R.S.; Ratajczak, J.; Doig, C.L.; Oakey, L.A.; Callingham, R.; Da Silva Xavier, G.; Garten, A.; Elhassan, Y.S.; Redpath, P.; Migaud, M.E.; Philp, A.; Brenner, C.; Canto, C.; Lavery, G.G.
    Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells (2017), Mol. Metab., 6, 819-832 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Mus musculus Q91W63
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Mus musculus Q9D7C9
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-

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle
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 Mus musculus
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Synonyms

Synonyms Comment Organism
nicotinamide riboside kinase 1
-
 Mus musculus
nicotinamide riboside kinase 2
-
 Mus musculus
NRK1
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 Mus musculus
Nrk2
-
 Mus musculus

General Information

General Information Comment Organism
malfunction NRK1, NRK2, and double KO myotubes reveal redundancy in the nicotinamide riboside kinase dependent metabolism of nicotinamide riboside to NAD+ Mus musculus
malfunction Nrk2 knockout mice develop normally and show subtle alterations to their NAD+ metabolome and expression of related genes. NRK1, NRK2, and double KO myotubes reveal redundancy in the nicotinamide riboside kinase dependent metabolism of nicotinamide riboside to NAD+ Mus musculus
physiological function NRK1 and 2 display overlapping function in salvage of exogenous nicotinamide riboside and NMN to augment intracellular NAD+ availability Mus musculus