Cloned (Comment) | Organism |
---|---|
gene NMRK2 | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of NRK2 knockout (KO) mice | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-(beta-D-ribofuranosyl)-nicotinamide | Mus musculus | - |
ADP + beta-nicotinamide D-ribonucleotide | - |
? | |
ATP + 1-(beta-D-ribofuranosyl)-nicotinamide | Mus musculus C57BL/6N | - |
ADP + beta-nicotinamide D-ribonucleotide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9NPI5 | - |
- |
Mus musculus | Q9D7C9 | - |
- |
Mus musculus C57BL/6N | Q9D7C9 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cardiac muscle | - |
Mus musculus | - |
fibroblast | - |
Mus musculus | - |
heart | predominantly expresses in skeletal muscle with a trace amount expressed in healthy cardiac tissue | Homo sapiens | - |
heart | predominantly expresses in skeletal muscle with a trace amount expressed in healthy cardiac tissue | Mus musculus | - |
myofibroblast | - |
Mus musculus | - |
skeletal muscle | - |
Mus musculus | - |
skeletal muscle | predominantly expresses in skeletal muscle with a trace amount expressed in healthy cardiac tissue | Homo sapiens | - |
skeletal muscle | predominantly expresses in skeletal muscle with a trace amount expressed in healthy cardiac tissue | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-(beta-D-ribofuranosyl)-nicotinamide | - |
Mus musculus | ADP + beta-nicotinamide D-ribonucleotide | - |
? | |
ATP + 1-(beta-D-ribofuranosyl)-nicotinamide | - |
Mus musculus C57BL/6N | ADP + beta-nicotinamide D-ribonucleotide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
muscle-specific beta1 integrin binding protein | - |
Mus musculus |
nicotinamide riboside kinase-2 | - |
Homo sapiens |
nicotinamide riboside kinase-2 | - |
Mus musculus |
NMRK2 | - |
Mus musculus |
NRK-2 | - |
Homo sapiens |
NRK-2 | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | NRK-2 expression dramatically increases in ischemic heart | up |
Mus musculus | NRK-2 expression dramatically increases in ischemic heart | up |
General Information | Comment | Organism |
---|---|---|
malfunction | loss of NRK-2 enhances p38alpha activation following ischemic injury | Mus musculus |
malfunction | NRK-2 plays a critical role in heart failure progression following ischemic injury. NRK-2 deficiency promotes post-MI scar expansion, rapid LV chamber dilatation, cardiac dysfunction and fibrosis possibly due to increased p38slphs activation | Homo sapiens |
malfunction | loss of NRK-2 enhanced p38alpha activation following ischemic injury. The gain of NRK-2 function suppresses the p38alpha as well as fibroblast activation (alpha-SMA expression) upon TGF-beta stimulation, and limits cardiomyocytes death upon hypoxia/re-oxygenation. Role of NRK-2 in ischemia-induced cardiac remodeling and dysfunction, overview | Mus musculus |
physiological function | NRK-2 plays a critical role in heart failure progression following ischemic injury. NRK-2 deficiency promotes post-MI scar expansion, rapid LV chamber dilatation, cardiac dysfunction and fibrosis possibly due to increased p38slphs activation | Homo sapiens |
physiological function | nicotinamide riboside kinase-2 (NRK-2) is a muscle-specific beta1 integrin binding protein, that is predominantly expressed in skeletal muscle with a trace amount expressed in healthy cardiac tissue. Nicotinamide riboside kinase-2 alleviates ischemia-induced heart failure through P38 signaling, role of NRK-2 in ischemia-induced cardiac remodeling and dysfunction, overview. NRK-2 plays a role in the NAD+ salvage pathway, but the role of NRK-2 in NAD+ synthesis is dispensable. NRK-2 may regulate cardiac pathophysiology of heart failure. NRK-2 mitigates TGF-beta-induced myofibroblast transformation | Mus musculus |