Literature summary for 2.7.1.219 extracted from

Zhang, X.; Carter, M.; Vetting, M.; Francisco, B.; Zhao, S.; Al-Obaidi, N.; Solbiati, J.; Thiaville, J.; Crecy-Lagard, V.; Jacobson, M.; Almo, S.; Gerlt, J.
Assignment of function to a domain of unknown function DUF1537 is a new kinase family in catabolic pathways for acid sugars (2016), Proc. Natl. Acad. Sci. USA, 113, E4161-E4169 .

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KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.12	-	D-threonate	pH 8.0, 25°C	Cupriavidus necator
0.29	-	D-threonate	pH 8.0, 25°C	Salmonella enterica subsp. enterica serovar Typhimurium
3.8	-	4-hydroxy-L-threonine	pH 8.0, 25°C	Salmonella enterica subsp. enterica serovar Typhimurium
86	-	4-hydroxy-L-threonine	pH 8.0, 25°C	Cupriavidus necator

Organism

Organism	UniProt	Comment	Textmining
Cupriavidus necator	Q0K4F6	member of the DUF1537 family, participates in catabolic pathways for four-carbon acid sugars	-
Cupriavidus necator DSM 428	Q0K4F6	member of the DUF1537 family, participates in catabolic pathways for four-carbon acid sugars	-
Salmonella enterica subsp. enterica serovar Typhimurium	Q8ZRS5	member of the DUF1537 family, participates in catabolic pathways for four-carbon acid sugars	-
Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720	Q8ZRS5	member of the DUF1537 family, participates in catabolic pathways for four-carbon acid sugars	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + 4-hydroxy-L-threonine	-	Salmonella enterica subsp. enterica serovar Typhimurium	ADP + 4-phospho-L-threonine	-	?
ATP + 4-hydroxy-L-threonine	-	Cupriavidus necator	ADP + 4-phospho-L-threonine	-	?
ATP + 4-hydroxy-L-threonine	-	Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720	ADP + 4-phospho-L-threonine	-	?
ATP + 4-hydroxy-L-threonine	-	Cupriavidus necator DSM 428	ADP + 4-phospho-L-threonine	-	?
ATP + D-threonate	-	Salmonella enterica subsp. enterica serovar Typhimurium	ADP + 4-phospho-D-threonate	-	?
ATP + D-threonate	-	Cupriavidus necator	ADP + 4-phospho-D-threonate	-	?
ATP + D-threonate	-	Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720	ADP + 4-phospho-D-threonate	-	?
ATP + D-threonate	-	Cupriavidus necator DSM 428	ADP + 4-phospho-D-threonate	-	?

Synonyms

Synonyms	Comment	Organism
D-threonate kinase	-	Salmonella enterica subsp. enterica serovar Typhimurium
D-threonate kinase	-	Cupriavidus necator
dtnK	-	Salmonella enterica subsp. enterica serovar Typhimurium
dtnK	-	Cupriavidus necator

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
4	-	4-hydroxy-L-threonine	pH 8.0, 25°C	Salmonella enterica subsp. enterica serovar Typhimurium
22	-	D-threonate	pH 8.0, 25°C	Salmonella enterica subsp. enterica serovar Typhimurium
27	-	4-hydroxy-L-threonine	pH 8.0, 25°C	Cupriavidus necator
45	-	D-threonate	pH 8.0, 25°C	Cupriavidus necator

General Information

General Information	Comment	Organism
physiological function	a gene deletion strain is unable to use D-threonate as a carbon source	Salmonella enterica subsp. enterica serovar Typhimurium
physiological function	a gene deletion strain is unable to use D-threonate as a carbon source	Cupriavidus necator

kcat/KM [mM/s]

kcat/KM Value [1/mMs^-1]	kcat/KM Value Maximum [1/mMs^-1]	Substrate	Comment	Organism	Structure
0.31	-	4-hydroxy-L-threonine	pH 8.0, 25°C	Cupriavidus necator
1.1	-	4-hydroxy-L-threonine	pH 8.0, 25°C	Salmonella enterica subsp. enterica serovar Typhimurium
75	-	D-threonate	pH 8.0, 25°C	Salmonella enterica subsp. enterica serovar Typhimurium
380	-	D-threonate	pH 8.0, 25°C	Cupriavidus necator

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Release 2023.1 (January 2023)