Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Calmodulin | stimulates the enzyme by 13.8%, might modify the activity, enzyme contains a calmodulin binding domain, Ca2+ is required for binding, compounds W7 and W13 prevent stimulation, overview | Dictyostelium discoideum |
Cloned (Comment) | Organism |
---|---|
gene thyB, DNA and amino acid sequence determination and analysis, phage display, location on chromosome 5, 3 exons, 2 introns, expression in Escherichia coli strain BL21 | Dictyostelium discoideum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
W7 | slight inhibitory in presence of calmodulin | Dictyostelium discoideum |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Dictyostelium discoideum | 5829 | - |
additional information | enzyme possesses no nuclear or transmembrane sequences | Dictyostelium discoideum | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | calmodulin binding binding is dependent on Ca2+ | Dictyostelium discoideum |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
25494 | - |
x * 25494, recombinant enzyme, amino acid sequence calculation | Dictyostelium discoideum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + thymidine | Dictyostelium discoideum | - |
ADP + thymidine 5'-phosphate | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Dictyostelium discoideum | Q27564 | - |
- |
Purification (Comment) | Organism |
---|---|
recombinant enzyme partially utilizing calmodulin-agarose-beads | Dictyostelium discoideum |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | enzyme is expressed during growth, but decreases in amount after starvation | Dictyostelium discoideum | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + thymidine | - |
Dictyostelium discoideum | ADP + thymidine 5'-phosphate | - |
ir |
Subunits | Comment | Organism |
---|---|---|
? | x * 25494, recombinant enzyme, amino acid sequence calculation | Dictyostelium discoideum |
More | enzyme contains a calmodulin binding domain | Dictyostelium discoideum |
Synonyms | Comment | Organism |
---|---|---|
calmodulin-binding protein | - |
Dictyostelium discoideum |
CaM-binding protein | - |
Dictyostelium discoideum |
CaMBP | - |
Dictyostelium discoideum |
ThyB | - |
Dictyostelium discoideum |
thymidine kinase 1 | - |
Dictyostelium discoideum |
TK1 | - |
Dictyostelium discoideum |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Dictyostelium discoideum |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Dictyostelium discoideum |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | P-loop binding site | Dictyostelium discoideum |