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Literature summary for 2.7.1.21 extracted from

  • Wang, L.; Eriksson, S.
    Cloning and characterization of full-length mouse thymidine kinase 2: the N-terminal sequence directs import of the precursor protein into mitochondria (2000), Biochem. J., 351, 469-476.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.21

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0034
-
 thymidine mTK2 pH 7.6 Mus musculus
0.0049
-
 thymidine mTK2-39 pH 7.6 Mus musculus
0.0073
-
 thymidine mTK2-55 pH 7.6 Mus musculus
0.0115
-
 deoxycytidine mTK2-55 pH 7.6 Mus musculus
0.0236
-
 deoxycytidine mTK2-39 pH 7.6 Mus musculus
0.0251
-
 deoxycytidine mTK2 pH 7.6 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
30000
-
 gel filtration, two enzyme forms of MW 30000 and 60000 Mus musculus
60000
-
 gel filtration, two enzyme forms of MW 30000 and 60000 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q9R088
-
-

Purification (Commentary)

Purification (Comment) Organism
3 forms Mus musculus

Storage Stability

Storage Stability Organism
4°C, MTK1-39 and mTK2-55 are stable for up to 3 weeks, mTK2 is less stable Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2'-deoxycytidine
-
 Mus musculus ADP + 2'-deoxycytidine 5'-phosphate
-
 ?
ATP + 2'-deoxyuridine
-
 Mus musculus ADP + 2'-deoxyuridine 5'-phosphate
-
 ?
ATP + thymidine
-
 Mus musculus ADP + dTMP
-
 ?
additional information overview: nucleoside analogs Mus musculus ?
-
 ?

Subunits

Subunits Comment Organism
dimer
-
 Mus musculus