Literature summary for 2.7.1.21 extracted from

Roberts, G.B.; Fyfe, J.A.; McKee, S.A.; Rahim, S.; Koszalka, G.W.; Krenitsky, T.A.
Varicella-zoster virus thymidine kinase. Characterization and substrate specificity (1993), Biochem. Pharmacol., 46, 2209-2218.

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Inhibitors

Inhibitors	Comment	Organism	Structure
dTTP	-	Human alphaherpesvirus 3

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0001	-	ATP	two active sites for ATP	Human alphaherpesvirus 3
0.0001	-	ATP	ATP in form of MgATP2-	Human alphaherpesvirus 3
0.9	-	ATP	two active sites for ATP	Human alphaherpesvirus 3
0.9	-	ATP	ATP in form of MgATP2-	Human alphaherpesvirus 3

Organism

Organism	UniProt	Comment	Textmining
Human alphaherpesvirus 3	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + thymidine	-	Human alphaherpesvirus 3	ADP + dTMP	-	?
additional information	overview thymine nucleosides, 2'-deoxyribonucleosides, arabinosides, ribonucleosides	Human alphaherpesvirus 3	?	-	?

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
additional information	-	-	Human alphaherpesvirus 3

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Release 2023.1 (January 2023)