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Literature summary for 2.7.1.21 extracted from

  • Her, M.O.; Momparler, R.L.
    Mammalian deoxynucleoside kinases. IV. Deoxythymidine kinase: purification, properties, and kinetic studies (1971), J. Biol. Chem., 246, 6152-6158.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
dTDP 83% inhibition at 0.1 mM Bos taurus
dTMP 8% inhibition at 0.1 mM Bos taurus
dTTP 84% inhibition at 0.1 mM Bos taurus
EDTA complete incactivation at 2.5 mM Bos taurus
potassium phosphate 80% inhibition at 50 mM Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.05
-
ATP pH 7, 37°C Bos taurus
0.057
-
thymidine pH 7, 37°C Bos taurus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
thymus
-
Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
7.5
-
-
Bos taurus

Storage Stability

Storage Stability Organism
-20°C, 50 mM Tris-HCl buffer, pH 8.0, 10 mM 2-mercaptoethanol, 20% glycerol, 100 mM KCl, 6 months, 20% loss of activity Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + cytosine arabinoside 5'-triphosphate
-
Bos taurus ADP + thymidine 5'-phosphate
-
?
ATP + thymidine ATP can be substituted by dGTP Bos taurus ADP + dTMP
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.006
-
dTTP pH 7, 37°C Bos taurus