Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.21 extracted from

  • Chraibi, R.; Wright, M.
    Characterization of the thymidine kinase of Physarum polycephalum (1983), J. Biochem., 93, 323-330.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
5-bromodeoxyuridine competitive to thymidine Physarum polycephalum
5-fluorodeoxyuridine competitive to thymidine Physarum polycephalum
5-iododeoxyuridine competitive to thymidine Physarum polycephalum
ADP competitive to ATP Physarum polycephalum
Caffeine competitive to ATP Physarum polycephalum
deoxyuridine
-
Physarum polycephalum
dGDP competitive to ATP Physarum polycephalum
dTDP competitive to ATP Physarum polycephalum
dTMP competitive to ATP Physarum polycephalum
dTTP non-competitive with thymidine, competitive to ATP Physarum polycephalum
dUTP competitive to ATP Physarum polycephalum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information
-
Physarum polycephalum

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ 7.5-10 mM, required Physarum polycephalum

Organism

Organism UniProt Comment Textmining
Physarum polycephalum
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Physarum polycephalum

Source Tissue

Source Tissue Comment Organism Textmining
plasmodium
-
Physarum polycephalum
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
100
-
-
Physarum polycephalum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + thymidine ATP can be substituted by dATP Physarum polycephalum ADP + dTMP
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5 9
-
Physarum polycephalum

pH Range

pH Minimum pH Maximum Comment Organism
7 9.5 less than 70% of maximal activity above and below Physarum polycephalum

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.001 0.0045 5-iododeoxyuridine pH 7.5, 27°C Physarum polycephalum
0.0015 0.0055 5-bromodeoxyuridine pH 7.5, 27°C Physarum polycephalum
0.014 0.036 dTTP pH 7.5, 27°C Physarum polycephalum
0.06 0.096 5-fluorodeoxyuridine pH 7.5, 27°C Physarum polycephalum
0.27 1.54 deoxyuridine pH 7.5, 27°C Physarum polycephalum
0.5 0.65 dTDP pH 7.5, 27°C Physarum polycephalum
3.6 4.7 dTMP pH 7.5, 27°C Physarum polycephalum