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Literature summary for 2.7.1.189 extracted from

  • Taga, M.E.; Miller, S.T.; Bassler, B.L.
    Lsr-mediated transport and processing of AI-2 in Salmonella typhimurium (2003), Mol. Microbiol., 50, 1411-1427.
    View publication on PubMed
Search for more literature for 2.7.1.189

Protein Variants

Protein Variants Comment Organism
additional information construction of an in frame deletion of the lsrK gene, phenotype, overview Salmonella enterica subsp. enterica serovar Typhimurium

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Salmonella enterica subsp. enterica serovar Typhimurium 5737
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + autoinducer-2 Salmonella enterica subsp. enterica serovar Typhimurium i.e. AI-2 ADP + phosphorylated autoinducer-2
-
 ?
ATP + autoinducer-2 Salmonella enterica subsp. enterica serovar Typhimurium MET235 i.e. AI-2 ADP + phosphorylated autoinducer-2
-
 ?

Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. enterica serovar Typhimurium
-
 gene lsrK
-
Salmonella enterica subsp. enterica serovar Typhimurium MET235
-
 gene lsrK
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + autoinducer-2 i.e. AI-2 Salmonella enterica subsp. enterica serovar Typhimurium ADP + phosphorylated autoinducer-2
-
 ?
ATP + autoinducer-2 i.e. AI-2 Salmonella enterica subsp. enterica serovar Typhimurium MET235 ADP + phosphorylated autoinducer-2
-
 ?

Synonyms

Synonyms Comment Organism
lsrK
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Expression

Organism Comment Expression
Salmonella enterica subsp. enterica serovar Typhimurium transcription of lsrK is not regulated by luxS or AI-2 additional information

General Information

General Information Comment Organism
malfunction in the DELTAlsrK deletion mutant, expression of the lsr-lacZ fusion is not induced by the presence of luxS or by exogenously supplied AI-2 in contrast to the wild-type. The enzyme activity and ATPase activity in the presence of culture fluids prepared from a luxS null strain is consistently lower than the background level Salmonella enterica subsp. enterica serovar Typhimurium
metabolism Lsr-mediated transport and processing of autoinducer 2, AI-2, overview Salmonella enterica subsp. enterica serovar Typhimurium
physiological function LsrK is required for the regulation of the lsr operon and the AI-2 uptake process. LsrK is a kinase that phosphorylates AI-2 upon entry into the cell, phosphorylation of AI-2 results in its sequestration in the cytoplasm Salmonella enterica subsp. enterica serovar Typhimurium