Literature summary for 2.7.1.189 extracted from

Li, J.; Attila, C.; Wang, L.; Wood, T.K.; Valdes, J.J.; Bentley, W.E.
Quorum sensing in Escherichia coli is signaled by AI-2/LsrR: effects on small RNA and biofilm architecture (2007), J. Bacteriol., 189, 6011-6020.

Search for more literature for 2.7.1.189

Cloned(Commentary)

Cloned (Comment)	Organism
gene lsrK	Escherichia coli

Protein Variants

Protein Variants	Comment	Organism
additional information	genomic deletion of gene lsrK. Genes lsrK and lsrR knockouts behave identically concerning the quantity and architecture of biofilms by affecting genes including flu and wza, small riboregulators respond to the QS regulators lsrR and lsrK, e.g. the sRNA cell division inhibitor DicF is induced by at least twofold in both lsrR and lsrK mutants. 117 and 32 genes are induced and repressed, respectively, by lsrK, transcriptosome analysis in enzyme mutants, overview	Escherichia coli

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	required	Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + autoinducer-2	Escherichia coli	i.e. AI-2	ADP + phosphorylated autoinducer-2	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	W3110, gene lsrK	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + autoinducer-2	i.e. AI-2	Escherichia coli	ADP + phosphorylated autoinducer-2	-	?

Synonyms

Synonyms	Comment	Organism
lsrK	-	Escherichia coli

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Escherichia coli

General Information

General Information	Comment	Organism
malfunction	deletion of lsrR and lsrK does not affect growth or motility. Genomic deletion of gene lsrK. Genes lsrK and lsrR knockouts behave identically concerning the quantity and architecture of biofilms by affecting genes including flu and wza, small riboregulators respond to the QS regulators lsrR and lsrK	Escherichia coli
metabolism	the regulatory network for the uptake of Escherichia coli autoinducer 2 (AI-2) is comprised of a transporter complex, LsrABCD, its repressor, LsrR, and the cognate signal kinase, LsrK. This network is an integral part of the AI-2 quorum-sensing system, extended model for AI-2 signaling, overview	Escherichia coli
physiological function	repressor LsrR and kinase LsrK directly regulate autoinducer 2, AI-2, uptake. Small riboregulators respond to the QS regulators lsrR and lsrK. 117 and 32 genes are induced and repressed, respectively, by lsrK	Escherichia coli

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)