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Literature summary for 2.7.1.189 extracted from
- Phosphoenolpyruvate phosphotransferase system regulates detection and processing of the quorum sensing signal autoinducer-2 (2012), Mol. Microbiol., 84, 93-104.
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Escherichia coli |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + autoinducer-2 | Escherichia coli | i.e. AI-2 | ADP + phosphorylated autoinducer-2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
gene lsrK | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + autoinducer-2 | i.e. AI-2 | Escherichia coli | ADP + phosphorylated autoinducer-2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| lsrK | - |
Escherichia coli |
| LsrK kinase | - |
Escherichia coli |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Escherichia coli | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | no induction of the lsr promoter occurs in the lsrK mutant strain, since the lsr promoter is activated by phosphorylated autoinducer-2. Intracellular accumulation of phosphorylated autoinducer-2 is not observed in a lsrK mutant | Escherichia coli |
| metabolism | autoinducer 2, AI-2, is imported by the Lsr and is phosphorylated by the LsrK kinase, and AI-2-phosphate is the inducer of the lsr operon. LsrK is necessary for the phosphorylation of AI-2, AI-2 is not phosphorylated by phosphoenolpyruvate phosphotransferase system, which is involved in the AI-2 internalization. Lsr-mediated transport and processing of AI-2 in Escherichia coli, overview | Escherichia coli |
| physiological function | enzyme LsrK activity, namely, AI-2 phosphorylation, is required to sequester the signal in the cytoplasm, independently of the mechanism of AI-2 internalization | Escherichia coli |
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