Cloned (Comment) | Organism |
---|---|
gene NMRK1 | Homo sapiens |
gene NMRK2 | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.051 | - |
beta-D-ribosylnicotinate | with ATP, pH and temperature not specified in the publication | Homo sapiens | |
0.063 | - |
beta-D-ribosylnicotinate | with ATP, pH and temperature not specified in the publication | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + beta-D-ribosylnicotinate | Homo sapiens | - |
ADP + nicotinate beta-D-ribonucleotide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9NPI5 | - |
- |
Homo sapiens | Q9NWW6 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + beta-D-ribosylnicotinate | - |
Homo sapiens | ADP + nicotinate beta-D-ribonucleotide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
More | see also EC 2.7.1.22 | Homo sapiens |
nicotinamide riboside kinase 1 | - |
Homo sapiens |
nicotinamide riboside kinase 2 | - |
Homo sapiens |
NMRK1 | - |
Homo sapiens |
NMRK2 | - |
Homo sapiens |
NRK1 | - |
Homo sapiens |
Nrk2 | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.21 | - |
beta-D-ribosylnicotinate | with ATP, pH and temperature not specified in the publication | Homo sapiens | |
0.34 | - |
beta-D-ribosylnicotinate | with ATP, pH and temperature not specified in the publication | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | Nmrk2 mRNA expression is substantially induced (over 80fold) in models of lethal cardiomyopathy | up |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme is involved in the NAD+ biosynthesis pathway. In the initial step of the pathway, NRK activity catalyses the phosphorylation of nicotinamide riboside (NR) to nicotinamide mononucleotide (NMN), see for EC 2.7.1.22. Importance of different salvage pathways involved in metabolising the vitamin B3 class of NAD+ precursor molecules, with a particular focus on the nicotinamide riboside kinase pathway at both a tissue-specific and systemic level, regulation of the NRK enzymes, overview. Alternatively, NRK activity can phosphorylate nicotinic acid riboside (NaR) to nicotinic acid mononucleotide (NaMN) | Homo sapiens |
additional information | proposed NRK expression in disease and potential therapeutic interventions | Homo sapiens |
physiological function | NRK2 appears to play a redundant role in NAD+ biosynthesis along with NRK1, at least in unchallenged models, its highly regulated expression particularly in times of stress suggest it may have role beyond NAD+ metabolism | Homo sapiens |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
4.12 | - |
beta-D-ribosylnicotinate | with ATP, pH and temperature not specified in the publication | Homo sapiens | |
5.4 | - |
beta-D-ribosylnicotinate | with ATP, pH and temperature not specified in the publication | Homo sapiens |