Literature summary for 2.7.1.171 extracted from

Dunmore, S.J.; Al-Derawi, A.S.; Nayak, A.U.; Narshi, A.; Nevill, A.M.; Hellwig, A.; Majebi, A.; Kirkham, P.; Brown, J.E.; Singh, B.M.
Evidence that differences in fructosamine-3-kinase activity may be associated with the glycation gap in human diabetes (2018), Diabetes, 67, 131-136 .

Search for more literature for 2.7.1.171

Application

Application	Comment	Organism
medicine	FN3K may be a potential predictor of the risk of diabetes complications. Pharmacological modifications of its activity may provide an approach to their prevention	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	required	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + [protein]-N6-D-fructosyl-L-lysine	Homo sapiens	-	ADP + [protein]-N6-(3-O-phospho-D-fructosyl)-L-lysine	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9H479	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
erythrocyte	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + [protein]-N6-D-fructosyl-L-lysine	-	Homo sapiens	ADP + [protein]-N6-(3-O-phospho-D-fructosyl)-L-lysine	-	?

Synonyms

Synonyms	Comment	Organism
FN3K	-	Homo sapiens
fructosamine-3-kinase	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	variations in the level of the deglycating enzyme fructosamine-3-kinase (FN3K) might be associated with the glycation gap (GGap), a phenomenon of a discrepancy between glycated hemoglobin levels and other indicators of average glycemia may be due to many factors. GGap is associated with differences in complications in patients with diabetes and may possibly be explained by dissimilarities in deglycation in turn leading to altered production of advanced glycation end products (AGEs). Increased erythrocyte FN3K concentrations and enzyme activity (323%) are determined in a population dichotomized for a large positive or negative GGap. This is associated with lower AGE levels in the negative-GGap group (79%), lower proinflammatory adipokines (leptin-to-adiponectin ratio) (73%), and much lower prothrombotic PAI-1 levels (19%). FN3K may play a key role in the GGap and thus diabetes complications	Homo sapiens

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Release 2023.1 (January 2023)