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Literature summary for 2.7.1.171 extracted from

  • Hellwig, A.; Scherber, A.; Koehler, C.; Hanefeld, M.; Henle, T.
    A new HPLC-based assay for the measurement of fructosamine-3-kinase (FN3K) and FN3K-related protein activity in human erythrocytes (2014), Clin. Chem. Lab. Med., 52, 93-101.
No PubMed abstract available
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Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [protein]-N6-D-fructosyl-L-lysine Homo sapiens
-
 ADP + [protein]-N6-(3-O-phospho-D-fructosyl)-L-lysine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9H479 gene FN3K
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + N-alpha-hippuryl-N-epsilon-psicosyllysine
-
 Homo sapiens ADP + ?
-
 ?
ATP + [protein]-N6-D-fructosyl-L-lysine
-
 Homo sapiens ADP + [protein]-N6-(3-O-phospho-D-fructosyl)-L-lysine
-
 ?
additional information development of a PLC-based assay with substrate N-alpha-hippuryl-N-epsilon-psicosyllysine for the measurement of fructosamine-3-kinase (FN3K) and FN3K-related protein activity in human erythrocytes, method evaluation, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
FN3K
-
 Homo sapiens
fructosamine-3-kinase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
additional information no correlations of enzyme activity with age, sex, body weight, blood cholesterol, or plasma glucose in an oral glucose tolerance test are observed. Subjects whose parents or siblings had a stroke show lower FN3K activity Homo sapiens
physiological function impact on glycation, and possibly on diabetic complications, is attributed to fructosamine-3-kinase (FN3K) and its related protein (FN3K-RP) because they degrade Amadori compounds in vivo. Individual differences in FN3K-RP activity might contribute to an individual risk for diabetic complications Homo sapiens