Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
55000 | - |
x * 55000, SDS-PAGE | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glycero-D-manno-heptose 7-phosphate + ATP | Escherichia coli | - |
D-glycero-beta-D-mannoheptose 1,7-bisphosphate + ADP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glycero-D-manno-heptose 7-phosphate + ATP | - |
Escherichia coli | D-glycero-beta-D-mannoheptose 1,7-bisphosphate + ADP | - |
? | |
D-glycero-D-manno-heptose 7-phosphate + ATP | bifunctional D-beta-D-heptose-7-phosphate kinase/D-beta-D-heptose-1-phosphate adenylyltransferase. Based on genomic sequence comparisons, bifunctional proteins are predicted to be present in several Gram-negative microorganisms, including Agrobacterium tumefaciens, Buchnera sp., Caulobacter crescentus, Salmonella typhimurium, Salmonella typhi, Vibrio cholerae, Yersinia pestis, Haemophilus influenzae, Helicobacter pylori and Pseudomonas aeruginosa. In contrast, individual genes encoding domains I and II independently are found in Ralstonia eutropha, Neisseria meningitidis and Neisseria gonorrhoeae. In these cases, it is proposed to use the nomenclature hldA and hldC to indicate the individual kinase- and adenylyltransferase-encoding genes, respectively | Escherichia coli | D-glycero-beta-D-mannoheptose 1,7-bisphosphate + ADP | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 55000, SDS-PAGE | Escherichia coli |
More | the N-terminal domain I spans amino acids 1-318 and shares structural features with members of the ribokinase family. The C-terminal domain II, which spans amino acids 344-477, has all the conserved features of the cytidylyltransferase superfamily | Escherichia coli |
Synonyms | Comment | Organism |
---|---|---|
bifunctional D-beta-D-heptose-7-phosphate kinase/D-beta-dheptose-1-phosphate adenylyltransferase | - |
Escherichia coli |