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Literature summary for 2.7.1.159 extracted from

  • Saiardi, A.; Cockcroft, S.
    Human ITPK1: a reversible inositol phosphate kinase/phosphatase that links receptor-dependent phospholipase C to Ca2+-activated chloride channels (2008), Sci. Signal., 1, 1-3.
    View publication on PubMed
Search for more literature for 2.7.1.159

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1D-myo-inositol-1,3,4,5,6-pentakisphosphate + ADP Homo sapiens enzyme catalyzes both forward and reverse reaction 1D-myo-inositol-3,4,5,6-tetrakisphosphate + ATP putative regulator of Ca2+-activated chloride channels. r
1D-myo-inositol-1,3,4,5-tetrakisphosphate + ATP Homo sapiens
-
 1D-myo-inositol-1,3,4,5,6-pentakisphosphate + ADP
-
 r
1D-myo-inositol-1,3,4,6-tetrakisphosphate + ATP Homo sapiens
-
 1D-myo-inositol-1,3,4,5,6-pentakisphosphate + ADP
-
 r
1D-myo-inositol-1,3,4-trisphosphate + ATP Homo sapiens
-
 1D-myo-inositol-1,3,4,5-tetrakisphosphate + ADP
-
 r
1D-myo-inositol-1,3,4-trisphosphate + ATP Homo sapiens
-
 1D-myo-inositol-1,3,4,6-tetrakisphosphate + ADP
-
 r
additional information Homo sapiens The phenomenon of intersubstrate transfer is only found in the human enzyme, which can use 1D-myo-inositol 1,3,4-trisphosphate to regulate increased cellular concentrations of 1D-myo-inositol-3,4,5,6-tetrakisphosphate ?
-
 ?
additional information Homo sapiens The enzyme can phosphorylate both 1D-myo-inositol-1,3,4-trisphosphate at the 5 or 6 positions and 1D-myo-inositol-3,4,5,6-tetrakisphosphate at the 1 position and can also dephosphorylate 1D-myo-inositol-1,3,4,5,6-pentaakisphosphate to 1D-myo-inositol-3,4,5,6-tetrakisphosphate ?
-
 ?
additional information Homo sapiens enzyme has both phosphatase and kinase activity ?
-
 ?
additional information Homo sapiens the various enzyme activities manifested by ITPK1 provide a molecular mechanism that allows the receptor-activated changes in phospholipase C activity and consequent increases in the concentration of 1D-myo-inositol 1,3,4-trisphosphate to regulate the abundance of 1D-myo-inositol-3,4,5,6-tetrakisphosphate ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1D-myo-inositol-1,3,4,5,6-pentakisphosphate + ADP enzyme catalyzes both forward and reverse reaction Homo sapiens 1D-myo-inositol-3,4,5,6-tetrakisphosphate + ATP putative regulator of Ca2+-activated chloride channels. r
1D-myo-inositol-1,3,4,5-tetrakisphosphate + ATP
-
 Homo sapiens 1D-myo-inositol-1,3,4,5,6-pentakisphosphate + ADP
-
 r
1D-myo-inositol-1,3,4,6-tetrakisphosphate + ATP
-
 Homo sapiens 1D-myo-inositol-1,3,4,5,6-pentakisphosphate + ADP
-
 r
1D-myo-inositol-1,3,4-trisphosphate + ATP
-
 Homo sapiens 1D-myo-inositol-1,3,4,5-tetrakisphosphate + ADP
-
 r
1D-myo-inositol-1,3,4-trisphosphate + ATP
-
 Homo sapiens 1D-myo-inositol-1,3,4,6-tetrakisphosphate + ADP
-
 r
additional information The phenomenon of intersubstrate transfer is only found in the human enzyme, which can use 1D-myo-inositol 1,3,4-trisphosphate to regulate increased cellular concentrations of 1D-myo-inositol-3,4,5,6-tetrakisphosphate Homo sapiens ?
-
 ?
additional information The enzyme can phosphorylate both 1D-myo-inositol-1,3,4-trisphosphate at the 5 or 6 positions and 1D-myo-inositol-3,4,5,6-tetrakisphosphate at the 1 position and can also dephosphorylate 1D-myo-inositol-1,3,4,5,6-pentaakisphosphate to 1D-myo-inositol-3,4,5,6-tetrakisphosphate Homo sapiens ?
-
 ?
additional information enzyme has both phosphatase and kinase activity Homo sapiens ?
-
 ?
additional information the various enzyme activities manifested by ITPK1 provide a molecular mechanism that allows the receptor-activated changes in phospholipase C activity and consequent increases in the concentration of 1D-myo-inositol 1,3,4-trisphosphate to regulate the abundance of 1D-myo-inositol-3,4,5,6-tetrakisphosphate Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
inositol 1,3,4-triphosphate 5/6 kinase
-
 Homo sapiens
ITPK1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ADP
-
 Homo sapiens
ATP
-
 Homo sapiens