Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | enzyme expression is slightly induced by heat shock | Entamoeba histolytica |
Cloned (Comment) | Organism |
---|---|
DNA and amino acid sequence determination and analysis, expression as GST-tagged enzyme in bacteria | Entamoeba histolytica |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1D-myo-inositol-1,3,4-trisphosphate | Entamoeba histolytica | - |
ADP + 1D-myo-inositol-1,3,4,5-tetrakisphosphate | - |
? | |
ATP + 1D-myo-inositol-1,3,4-trisphosphate | Entamoeba histolytica | - |
ADP + 1D-myo-inositol-1,3,4,6-tetrakisphosphate | - |
? | |
ATP + 1D-myo-inositol-1,3,4-trisphosphate | Entamoeba histolytica HM-1 | - |
ADP + 1D-myo-inositol-1,3,4,5-tetrakisphosphate | - |
? | |
ATP + 1D-myo-inositol-1,3,4-trisphosphate | Entamoeba histolytica HM-1 | - |
ADP + 1D-myo-inositol-1,3,4,6-tetrakisphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Entamoeba histolytica | Q9XYQ1 | - |
- |
Entamoeba histolytica HM-1 | Q9XYQ1 | - |
- |
Purification (Comment) | Organism |
---|---|
recombinant GST-tagged enzyme, the GST-tag is cleaved off by treatment with GST-3Cpro | Entamoeba histolytica |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Entamoeba histolytica |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1D-myo-inositol-1,3,4-trisphosphate | - |
Entamoeba histolytica | ADP + 1D-myo-inositol-1,3,4,5-tetrakisphosphate | - |
? | |
ATP + 1D-myo-inositol-1,3,4-trisphosphate | - |
Entamoeba histolytica | ADP + 1D-myo-inositol-1,3,4,5-tetrakisphosphate | the formation of 1D-myo-inositol-1,3,4,6-tetrakisphosphate is slightly preferred compared to formation of 1D-myo-inositol-1,3,4,5-tetrakisphosphate, ratio 1.5:1 | ? | |
ATP + 1D-myo-inositol-1,3,4-trisphosphate | - |
Entamoeba histolytica HM-1 | ADP + 1D-myo-inositol-1,3,4,5-tetrakisphosphate | - |
? | |
ATP + 1D-myo-inositol-1,3,4-trisphosphate | - |
Entamoeba histolytica HM-1 | ADP + 1D-myo-inositol-1,3,4,5-tetrakisphosphate | the formation of 1D-myo-inositol-1,3,4,6-tetrakisphosphate is slightly preferred compared to formation of 1D-myo-inositol-1,3,4,5-tetrakisphosphate, ratio 1.5:1 | ? | |
ATP + 1D-myo-inositol-1,3,4-trisphosphate | - |
Entamoeba histolytica | ADP + 1D-myo-inositol-1,3,4,6-tetrakisphosphate | - |
? | |
ATP + 1D-myo-inositol-1,3,4-trisphosphate | - |
Entamoeba histolytica | ADP + 1D-myo-inositol-1,3,4,6-tetrakisphosphate | the formation of 1D-myo-inositol-1,3,4,6-tetrakisphosphate is slightly preferred compared to formation of 1D-myo-inositol-1,3,4,5-tetrakisphosphate, ratio 1.5:1 | ? | |
ATP + 1D-myo-inositol-1,3,4-trisphosphate | - |
Entamoeba histolytica HM-1 | ADP + 1D-myo-inositol-1,3,4,6-tetrakisphosphate | - |
? | |
ATP + 1D-myo-inositol-1,3,4-trisphosphate | - |
Entamoeba histolytica HM-1 | ADP + 1D-myo-inositol-1,3,4,6-tetrakisphosphate | the formation of 1D-myo-inositol-1,3,4,6-tetrakisphosphate is slightly preferred compared to formation of 1D-myo-inositol-1,3,4,5-tetrakisphosphate, ratio 1.5:1 | ? | |
additional information | the enzyme also preferably performs the phosphoinositol trisphosphate 3-kinase reaction with 1D-myo-inositol-1,4,5-trisphosphate as substrate, EC 2.7.1.127, no activity with 1D-myo-inositol-1,4-bisphosphate | Entamoeba histolytica | ? | - |
? | |
additional information | the enzyme also preferably performs the phosphoinositol trisphosphate 3-kinase reaction with 1D-myo-inositol-1,4,5-trisphosphate as substrate, EC 2.7.1.127, no activity with 1D-myo-inositol-1,4-bisphosphate | Entamoeba histolytica HM-1 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Ins(1,3,4)P3 5/6-kinase | - |
Entamoeba histolytica |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Entamoeba histolytica |