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Literature summary for 2.7.1.154 extracted from

  • MacDougall, L.K.; Gagou, M.E.; Leevers, S.J.; Hafen, E.; Waterfield, M.D.
    Targeted expression of the class II phosphoinositide 3-kinase in Drosophila melanogaster reveals lipid kinase-dependent effects on patterning and interactions with receptor signaling pathways (2004), Mol. Cell. Biol., 24, 796-808.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression of class I isozyme Dp110 enhances organ size by increasing the size of cells without perturbing patterning, ectopic expression of wild-type and catalytically inactive mutant of class II isozyme PI3K_68D in different patterns during Drosophila melanogaster disk development, phenotype analysis of adult cuticle Drosophila melanogaster

Protein Variants

Protein Variants Comment Organism
additional information the catalytically inactive mutant of class II isozyme PI3K_68D can bind the Drk adaptor protein in vitro Drosophila melanogaster

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate Drosophila melanogaster
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ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
-
?
additional information Drosophila melanogaster the isozymes interact with and effect patterning of receptor signaling pathways, overview ?
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?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
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diverse strains
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Source Tissue

Source Tissue Comment Organism Textmining
cuticle
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Drosophila melanogaster
-
larva
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Drosophila melanogaster
-
additional information isozyme expression pattern and phenotype, Drk adaptor protein might be involved in localization of the isozymes, overview Drosophila melanogaster
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
Drosophila melanogaster ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
-
?
additional information the isozymes interact with and effect patterning of receptor signaling pathways, overview Drosophila melanogaster ?
-
?

Synonyms

Synonyms Comment Organism
class I phosphoinositide 3-kinase
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Drosophila melanogaster
class II phosphoinositide 3-kinase
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Drosophila melanogaster
class III phosphoinositide 3-kinase
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Drosophila melanogaster
phosphoinositide 3-kinase
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Drosophila melanogaster
PI3K
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Drosophila melanogaster