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Literature summary for 2.7.1.153 extracted from

  • Thapa, N.; Choi, S.; Tan, X.; Wise, T.; Anderson, R.A.
    Phosphatidylinositol phosphate 5-kinase Igamma and phosphoinositide 3-kinase/Akt signaling couple to promote oncogenic growth (2015), J. Biol. Chem., 290, 18843-18854.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.153

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Homo sapiens 5886
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Homo sapiens
-
 ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P42336 gene PI3KCA ; gene PI3KCA
-
Homo sapiens P42338 gene PI3KCB; gene PI3KCB
-

Source Tissue

Source Tissue Comment Organism Textmining
CAL-51 cell
-
 Homo sapiens
-
HEK-293 cell
-
 Homo sapiens
-
HEK-293FT cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
MDA-MB-231 cell
-
 Homo sapiens
-
NIH-3T3 cell
-
 Homo sapiens
-
SUM-1315MO2 cell
-
 Homo sapiens
-
SUM-159PT cell
-
 Homo sapiens
-
T-47D cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
 ?

Synonyms

Synonyms Comment Organism
class I PI3K
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism analysis of the mechanism by which phosphatidylinositol 4-phosphate 5-kinase Igammai2 and PI3K are integrated into a complex regulated by Src, resulting in the spatial generation of PIP2, which is the substrate PI3K required for PIP3 generation and subsequent Akt activation, the PIP2-generating enzyme controls Akt activation upstream of a PI3K enzyme Homo sapiens
physiological function enzyme PI3K is rapidly recruited to activated growth factor receptors (SH2 domain of the adaptor subunit mediating the interaction to the phosphorylated YXXM motif of the receptor) or integrin-mediated adhesion complex (via interaction with focal adhesion kinase in the adhesion complex), promoting its activation and 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate synthesis. phosphatidylinositol 4-phosphate 5-kinase Igamma, EC 2.7.1.68, is the major PIPKI enzyme contributing to PI3K/Akt signaling in response to activation of growth factor and adhesion receptors in suspension condition, overview Homo sapiens