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Literature summary for 2.7.1.153 extracted from

  • Vantler, M.; Jesus, J.; Leppaenen, O.; Scherner, M.; Berghausen, E.M.; Mustafov, L.; Chen, X.; Kramer, T.; Zierden, M.; Gerhardt, M.; Ten Freyhaus, H.; Blaschke, F.; Sterner-Kock, A.; Baldus, S.; Zhao, J.J.; Rosenkranz, S.
    Class IA phosphatidylinositol 3-kinase isoform p110alpha mediates vascular remodeling (2015), Arterioscler. Thromb. Vasc. Biol., 35, 1434-1444.
    View publication on PubMed
Search for more literature for 2.7.1.153

Protein Variants

Protein Variants Comment Organism
additional information generation of a mouse model of smooth muscle cellĀ–specific p110alpha deficiency. Targeted deletion of p110alpha in sm-p110alpha-/- mice blunts growth factorĀ–induced cellular responses and abolishes neointima formation after balloon injury of the carotid artery in mice. p110 Subunit knockdown via specific siRNA application Mus musculus
additional information generation of a mouse model of smooth muscle cellĀ–specific p110delta deficiency. Targeted deletion of p110delta doe not affect vascular remodeling in vivo. p110 Subunit knockdown via specific siRNA application Mus musculus
additional information p110 subunit knockdown via specific siRNA application Rattus norvegicus
additional information p110 subunit knockdown via specific siRNA application Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
IC-87114 p110delta-specific small molecule inhibitor Homo sapiens
IC-87114 p110delta-specific small molecule inhibitor Rattus norvegicus
PIK-75 p110alpha-specific small molecule inhibitor Homo sapiens
PIK-75 p110alpha-specific small molecule inhibitor; p110alpha-specific small molecule inhibitor Mus musculus
PIK-75 p110alpha-specific small molecule inhibitor Rattus norvegicus
TGX-221 p110beta-specific small molecule inhibitor Homo sapiens
TGX-221 p110beta-specific small molecule inhibitor Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Rattus norvegicus
Mg2+ required Homo sapiens
Mg2+ required Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
85000
-
-
 Rattus norvegicus
85000
-
-
 Homo sapiens
85000
-
-
 Mus musculus
110000
-
-
 Rattus norvegicus
110000
-
-
 Homo sapiens
110000
-
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Rattus norvegicus
-
 ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
 ?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Homo sapiens
-
 ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
 ?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Mus musculus
-
 ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O00329 catalytic subunit p110delta; isozyme PI3Kdelta
-
Homo sapiens P42336 catalytic subunit p110alpha; isozyme PI3Kalpha
-
Homo sapiens P42338 catalytic subunit p110beta; isozyme PI3Kbeta
-
Mus musculus O35904 catalytic subunit p110delta; isozyme PI3Kdelta
-
Mus musculus P42337 catalytic subunit p110alpha; isozyme PI3Kalpha
-
Rattus norvegicus
-
 isozyme PI3Kdelta
-
Rattus norvegicus A0A0G2K344 catalytic subunit p110alpha; isozyme PI3Kalpha
-
Rattus norvegicus Q9Z1L0 catalytic subunit p110beta; isozyme PI3Kbeta
-

Source Tissue

Source Tissue Comment Organism Textmining
aortic smooth muscle cell
-
 Rattus norvegicus
-
coronary artery smooth muscle cell
-
 Homo sapiens
-
additional information expression and platelet-derived growth factor beta receptor (betaPDGFR) binding of p110 isoforms in smooth muscle cells (SMCs), overview Rattus norvegicus
-
additional information expression and platelet-derived growth factor beta receptor (betaPDGFR) binding of p110 isoforms in smooth muscle cells (SMCs), overview Homo sapiens
-
additional information expression and platelet-derived growth factor beta receptor (betaPDGFR) binding of p110 isoforms in smooth muscle cells (SMCs), overview Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 Rattus norvegicus ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
 ?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
 ?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 Mus musculus ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
 ?

Subunits

Subunits Comment Organism
heterodimer 1 * 110000, subunit p110, + 1 * 85000, subunit p85, class IA PI3K isoforms are heterodimers consisting of a catalytic subunit (p110alpha) and a smaller regulatory subunit (p85) Mus musculus
heterodimer 1 * 110000, subunit p110, + 1 * 85000, subunit p85, class IA PI3K isoforms are heterodimers consisting of a catalytic subunit (p110alpha) and a smaller regulatory subunit (p85) Homo sapiens
heterodimer 1 * 110000, subunit p110, + 1 * 85000, subunit p85, class IA PI3K isoforms are heterodimers consisting of a catalytic subunit (p110alpha) and a smaller regulatory subunit (p85) Rattus norvegicus
heterodimer 1 * 110000, subunit p110, + 1 * 85000, subunit p85, class IA PI3K isoforms are heterodimers consisting of a catalytic subunit (p110beta) and a smaller regulatory subunit (p85) Homo sapiens
heterodimer 1 * 110000, subunit p110, + 1 * 85000, subunit p85, class IA PI3K isoforms are heterodimers consisting of a catalytic subunit (p110beta) and a smaller regulatory subunit (p85) Rattus norvegicus
heterodimer 1 * 110000, subunit p110, + 1 * 85000, subunit p85, class IA PI3K isoforms are heterodimers consisting of a catalytic subunit (p110delta) and a smaller regulatory subunit (p85) Rattus norvegicus
heterodimer 1 * 110000, subunit p110, + 1 * 85000, subunit p85, class IA PI3K isoforms are heterodimers consisting of a catalytic subunit (p110delta) and a smaller regulatory subunit (p85) Homo sapiens
heterodimer 1 * 110000, subunit p110, + 1 * 85000, subunit p85, class IA PI3K isoforms are heterodimers consisting of a catalytic subunit (p110delta) and a smaller regulatory subunit (p85) Mus musculus

Synonyms

Synonyms Comment Organism
p110alpha catalytic subunit Mus musculus
p110alpha catalytic subunit Homo sapiens
p110alpha catalytic subunit Rattus norvegicus
p110beta catalytic subunit Homo sapiens
p110beta catalytic subunit Rattus norvegicus
p110delta catalytic subunit Rattus norvegicus
p110delta catalytic subunit Homo sapiens
p110delta catalytic subunit Mus musculus
phosphatidyl-inositol-3-kinase
-
 Rattus norvegicus
phosphatidyl-inositol-3-kinase
-
 Homo sapiens
phosphatidyl-inositol-3-kinase
-
 Mus musculus
phosphatidylinositol 3'-kinase
-
 Rattus norvegicus
phosphatidylinositol 3'-kinase
-
 Homo sapiens
phosphatidylinositol 3'-kinase
-
 Mus musculus
PI3Kalpha
-
 Mus musculus
PI3Kalpha
-
 Homo sapiens
PI3Kalpha
-
 Rattus norvegicus
PI3Kbeta
-
 Homo sapiens
PI3Kbeta
-
 Rattus norvegicus
PI3Kdelta
-
 Rattus norvegicus
PI3Kdelta
-
 Homo sapiens
PI3Kdelta
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus
ATP
-
 Homo sapiens
ATP
-
 Mus musculus

General Information

General Information Comment Organism
malfunction p110delta deficiency did not affect vascular remodeling in vivo Rattus norvegicus
malfunction p110delta deficiency did not affect vascular remodeling in vivo Mus musculus
physiological function class Ia phosphatidylinositol 3-kinase isoform p110alpha is crucial for receptor tyrosine kinases signaling, thus affecting proliferation, migration, and survival of smooth muscle cells, Receptor tyrosine kinasesĀ–induced phosphatidylinositol 3'-kinase signaling via the p110alpha isoform plays a central role for vascular remodeling Mus musculus
physiological function class Ia phosphatidylinositol 3-kinase isoform p110alpha is crucial for receptor tyrosine kinases signaling, thus affecting proliferation, migration, and survival of smooth muscle cells, Receptor tyrosine kinasesĀ–induced phosphatidylinositol 3'-kinase signaling via the p110alpha isoform plays a central role for vascular remodeling Homo sapiens
physiological function class Ia phosphatidylinositol 3-kinase isoform p110alpha is crucial for receptor tyrosine kinases signaling, thus affecting proliferation, migration, and survival of smooth muscle cells, Receptor tyrosine kinasesĀ–induced phosphatidylinositol 3'-kinase signaling via the p110alpha isoform plays a central role for vascular remodeling Rattus norvegicus
physiological function class Ia phosphatidylinositol 3-kinase isoform p110beta is disensible for receptor tyrosine kinases signaling, not affecting proliferation, migration, and survival of smooth muscle cells Homo sapiens
physiological function class Ia phosphatidylinositol 3-kinase isoform p110beta is disensible for receptor tyrosine kinases signaling, not affecting proliferation, migration, and survival of smooth muscle cells Rattus norvegicus
physiological function class Ia phosphatidylinositol 3-kinase isoform p110delta is disensible for receptor tyrosine kinases signaling, p110delta exerts noncatalytic functions in smooth muscle cell proliferation, but had no effect on migration Rattus norvegicus
physiological function class Ia phosphatidylinositol 3-kinase isoform p110delta is disensible for receptor tyrosine kinases signaling, p110delta exerts noncatalytic functions in smooth muscle cell proliferation, but had no effect on migration Homo sapiens
physiological function class Ia phosphatidylinositol 3-kinase isoform p110delta is disensible for receptor tyrosine kinases signaling, p110delta exerts noncatalytic functions in smooth muscle cell proliferation, but had no effect on migration Mus musculus