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Literature summary for 2.7.1.153 extracted from

  • Kong, D.; Zhang, Y.; Yamori, T.; Duan, H.; Jin, M.
    Inhibitory activity of flavonoids against class I phosphatidylinositol 3-kinase isoforms (2011), Molecules, 16, 5159-5167.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
Baicalin 10 microM, 35.5% inhibition of isoform PI3Kalpha Homo sapiens
luteolin 1 microM, 75.8% inhibition of isoform PI3Kalpha Homo sapiens
additional information inhibitory activity of eighteen flavonoids and deduction of their structure-activity relationships. The number of hydroxyl groups in the A and B rings might promote the activity, while loss of C2-C3 double bond might reduce the activity. The results indicate that the flavonoids seem to exhibit more potent activity on PI3Kalpha and delta isoforms compared with that on PI3Kbeta and gamma isoforms Homo sapiens
myricetin 1 microM, almost complete inhibition of isoform PI3Kalpha Homo sapiens
quercetagetin 1 microM, almost complete inhibition of isoform PI3Kalpha Homo sapiens
quercetin 1 microM, 54.1% inhibition of isoform PI3Kalpha Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation recombinant isoforms PI3Kalpha, beta, delta and gamma Homo sapiens
-