Literature summary for 2.7.1.153 extracted from

Randis, T.M.; Puri, K.D.; Zhou, H.; Diacovo, T.G.
Role of PI3Kdelta and PI3Kgamma in inflammatory arthritis and tissue localization of neutrophils (2008), Eur. J. Immunol., 38, 1215-1224.

Search for more literature for 2.7.1.153

Application

Application	Comment	Organism
medicine	genetic deletion or selective inhibition of isoform PI3Kdelta diminishes joint erosion to a level comparable to its PI3Kgamma counterpart. The induction and progression of joint destruction is profoundly reduced in the absence of both PI3K isoforms and correlates with a limited ability of neutrophils to migrate into tissue in response to leukotriene B4. fMLP-induced neutrophil extravasation is primarily reliant on PI3Kgamma	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	genetic deletion or selective inhibition of isoform PI3Kdelta diminishes joint erosion to a level comparable to its PI3Kgamma counterpart. The induction and progression of joint destruction is profoundly reduced in the absence of both PI3K isoforms and correlates with a limited ability of neutrophils to migrate into tissue in response to leukotriene B4. fMLP-induced neutrophil extravasation is primarily reliant on PI3Kgamma	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	K/BxN serum transfer model of arthritis, isoforms PI3Kdelta and PI3Kgamma	-

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Release 2023.1 (January 2023)