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Literature summary for 2.7.1.151 extracted from

  • Riley, A.M.; Deleu, S.; Qian, X.; Mitchell, J.; Chung, S.; Adelt, S.; Vogel, G.; Potter, B.V.; Shears, S.B.
    On the contribution of stereochemistry to human ITPK1 specificity: Ins(1,4,5,6)P4 is not a physiologic substrate (2006), FEBS Lett., 580, 324-330.
    View publication on PubMed
Search for more literature for 2.7.1.151

Inhibitors

Inhibitors Comment Organism Structure
inositol(1,3,4)-trisphosphate potently inhibits hITPK1 activity towards insositol (3,4,5,6)-tetrakisphosphate, IC50: 0.0076 mM Homo sapiens
inositol(3,5,6)-trisphosphate IC50: 0.1 mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00018
-
 inositol (1,4,5,6)-tetrakisphosphate
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens inositol (1,4,5,6)-tetrakisphosphate is not a physiological substrate ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 recombinant
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
inositol (1,4,5,6)-tetrakisphosphate + ATP hITPK1 has more than 13000fold preference for inositol (3,4,5,6)-tetrakisphosphate over its enantiomer inositol (1,4,5,6)-tetrakisphosphate Homo sapiens inositol (1,3,4,5,6)-pentakisphosphate + ADP
-
 ?
inositol (3,4,5,6)-tetrakisphosphate + ATP hITPK1 has more than 13000fold preference for inositol (3,4,5,6)-tetrakisphosphate over its enantiomer inositol (1,4,5,6)-tetrakisphosphate Homo sapiens inositol (1,3,4,5,6)-pentakisphosphate + ADP
-
 ?
additional information inositol (1,4,5,6)-tetrakisphosphate is not a physiological substrate Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ITPK1
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00015
-
 inositol (1,3,4)-trisphosphate
-
 Homo sapiens
0.002
-
 inositol (3,5,6)-trisphosphate
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0076
-
 potently inhibits hITPK1 activity towards insositol (3,4,5,6)-tetrakisphosphate, IC50: 0.0076 mM Homo sapiens inositol(1,3,4)-trisphosphate
0.1
-
 IC50: 0.1 mM Homo sapiens inositol(3,5,6)-trisphosphate