Cloned (Comment) | Organism |
---|---|
expression in enzyme-deficient yeast cells, stable overexpression in HEK-293 cells, abrogates the in vivo elevation of 1D-myo-inositol 1,4,5,6-tetrakisphosphate from the Salmonella dublin SopB protein | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00011 | - |
1D-myo-inositol 1,4,5-trisphosphate | recombinant enzyme, pH 7.2, 37°C | Homo sapiens | |
0.000112 | - |
inositol (1,4,5)-trisphosphate | 37°C, pH 7.2 | Homo sapiens | |
0.000129 | - |
inositol (1,3,4,5)-tetrakisphosphate | 37°C, pH 7.2 | Homo sapiens | |
0.00013 | - |
1D-myo-inositol 1,3,4,5-tetrakisphosphate | recombinant enzyme, pH 7.2, 37°C | Homo sapiens | |
0.00022 | - |
1D-myo-inositol 1,4,5,6-tetrakisphosphate | recombinant enzyme, pH 7.2, 37°C | Homo sapiens | |
0.000222 | - |
1D-myo-inositol-1,4,5,6-tetrakisphosphate | 37°C, pH 7.2 | Homo sapiens | |
0.000295 | - |
inositol (1,3,4,6)-tetrakisphosphate | 37°C, pH 7.2 | Homo sapiens | |
0.0003 | - |
1D-myo-inositol 1,3,4,6-tetrakisphosphate | recombinant enzyme, pH 7.2, 37°C | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
K+ | - |
Homo sapiens | |
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate | Homo sapiens | - |
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate | Homo sapiens | recombinant enzyme in yeast mutant cells | ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | - |
? | |
ATP + inositol 1,4,5,6-tetrakisphosphate | Homo sapiens | stable over-expression of the human protein in HEK-293 cells abrogates the in vivo elevation of inositol 1,4,5,6-tetrakisphosphate from the Salmonella dublin SopB protein. The enzyme may play a role in regulation of the level of inositol 1,4,5,6-tetrakisphosphate in human cells | ADP + inositol (1,3,4,5,6)-pentakisphosphate | - |
? | |
additional information | Homo sapiens | the enzyme regulates inositol 1,4,5,6-tetrakisphosphate | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | - |
recombinant | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | low activity | Homo sapiens | ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate | - |
Homo sapiens | ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate | preferred substrate | Homo sapiens | ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate | - |
Homo sapiens | ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate | recombinant enzyme in yeast mutant cells | Homo sapiens | ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,4,5-trisphosphate | - |
Homo sapiens | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
ATP + inositol 1,3,4,5-tetrakisphosphate | substrate preference for inositol 1,3,4,6-tetrakisphosphate over inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate | Homo sapiens | ADP + inositol (1,3,4,5,6)-pentakisphosphate | - |
? | |
ATP + inositol 1,4,5,6-tetrakisphosphate | - |
Homo sapiens | ADP + inositol (1,3,4,5,6)-pentakisphosphate | - |
? | |
ATP + inositol 1,4,5,6-tetrakisphosphate | stable over-expression of the human protein in HEK-293 cells abrogates the in vivo elevation of inositol 1,4,5,6-tetrakisphosphate from the Salmonella dublin SopB protein. The enzyme may play a role in regulation of the level of inositol 1,4,5,6-tetrakisphosphate in human cells | Homo sapiens | ADP + inositol (1,3,4,5,6)-pentakisphosphate | - |
? | |
ATP + inositol 1,4,5-trisphosphate | substrate preference for inositol 1,3,4,6-tetrakisphosphate over inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate | Homo sapiens | ADP + inositol (1,3,4,5)-tetrakisphosphate | - |
? | |
inositol (1,3,4,6)-tetrakisphosphate + ATP | substrate preference for inositol 1,3,4,6-tetrakisphosphate over inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate | Homo sapiens | ADP + inositol (1,3,4,5,6)-pentakisphosphate | - |
? | |
additional information | the enzyme regulates inositol 1,4,5,6-tetrakisphosphate | Homo sapiens | ? | - |
? | |
additional information | substrate specificity model, the enzyme shows inositol phosphate 5-kinase activity, overview | Homo sapiens | ? | - |
? | |
additional information | enzyme has a preferred 5-kinase activity over 3-kinase and 6-kinase activities | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
5-kinase | - |
Homo sapiens |
inositol phosphate multikinase | - |
Homo sapiens |
inositol polyphosphate multikinase | - |
Homo sapiens |
IPMK | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |