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Literature summary for 2.7.1.150 extracted from

  • Bridges, D.; Ma, J.T.; Park, S.; Inoki, K.; Weisman, L.S.; Saltiel, A.R.
    Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1 (2012), Mol. Biol. Cell, 23, 2955-2962.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
3T3-L1 cell
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 Mus musculus
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General Information

General Information Comment Organism
physiological function PIKFYVE knockdown produces a 36% reduction in phosphatidylinositol 3,5-bisphosphate and a 13% increase in phosphatidylinositol 3-phosphate. PIKFYVE and class II phosphatidylinositol 3-kinase PI3K-C2alpha are necessary for activation of the kinase complex mechanistic target of rapamycin mTORC1 and its translocation to the plasma membrane in 3T3-L1 adipocytes. The mTORC1 component Raptor directly interacts with phosphatidylinositol 3,5-bisphosphate Mus musculus