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Literature summary for 2.7.1.15 extracted from
- Identification and characterization of human ribokinase and comparison of its properties with E. coli ribokinase and human adenosine kinase (2007), FEBS Lett., 581, 3211-3216.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| phosphate | increases catalytic activity. KM-for ribose and ATP decreases in a concentration-dependent manner | Homo sapiens |  |
| phosphate | marked dependency upon the presence of inorganic phosphate | Homo sapiens | |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Escherichia coli |
| expression in Escherichia coli | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-carboxyethylphosphonic acid | - |
Escherichia coli | |
| 2-carboxyethylphosphonic acid | - |
Homo sapiens | |
| ATP | substrate inhibition | Escherichia coli | |
| ATP | substrate inhibition | Homo sapiens | |
| clodronate | - |
Escherichia coli | |
| clodronate | - |
Homo sapiens | |
| D-ribose | substrate inhibition | Escherichia coli | |
| D-ribose | substrate inhibition | Homo sapiens | |
| etidronate | - |
Escherichia coli | |
| etidronate | - |
Homo sapiens | |
| N-(phosphonomethyl)-glycine | - |
Escherichia coli | |
| N-(phosphonomethyl)-glycine | - |
Homo sapiens | |
| N-(phosphonomethyl)iminodiacetic acid | - |
Escherichia coli | |
| N-(phosphonomethyl)iminodiacetic acid | - |
Homo sapiens | |
| Phosphonoacetic acid | - |
Escherichia coli | |
| Phosphonoacetic acid | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.07 | - |
ATP | 37°C, pH 7.0, in presence of 5 mM phosphate | Homo sapiens | |
| 0.08 | - |
ATP | 37°C, pH 7.0, in presence of 2 mM phosphate | Homo sapiens | |
| 0.1 | - |
ATP | 37°C, pH 7.0, in presence of 1 mM phosphate | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Escherichia coli |
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + D-arabinose | weak activity | Homo sapiens | ? | - |
? | |
| ATP + D-ribose | - |
Escherichia coli | ADP + D-ribose 5-phosphate | - |
? | |
| ATP + D-ribose | - |
Homo sapiens | ADP + D-ribose 5-phosphate | - |
? | |
| ATP + D-ribose | highly specific for ribose phosphorylation | Homo sapiens | ADP + D-ribose 5-phosphate | - |
? | |
| additional information | no significant phosphorylation of D-fructose, D-galactose and D-xylose | Homo sapiens | ? | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Homo sapiens | |
| 1.2 | - |
ATP | 37°C, pH 7.0, in presence of 1 mM phosphate | Homo sapiens | |
| 4.4 | - |
ATP | 37°C, pH 7.0, in presence of 2 mM phosphate | Homo sapiens | |
| 18.91 | - |
ATP | 37°C, pH 7.0, in presence of 5 mM phosphate | Homo sapiens | |
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