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Literature summary for 2.7.1.15 extracted from

  • Schimmel, S.D.; Hoffee, P.; Horecker, B.L.
    Deoxyribokinase from Salmonella typhimurium. Purification and properties (1974), Arch. Biochem. Biophys., 164, 560-570.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Li+
-
Salmonella enterica subsp. enterica serovar Typhimurium
additional information 2-deoxyribose-5-phosphate and ADP at concentrations up to 5.4 and 10 mM do not inhibit the reaction with nonsaturating levels of substrates Salmonella enterica subsp. enterica serovar Typhimurium
Na+
-
Salmonella enterica subsp. enterica serovar Typhimurium

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.1
-
2-deoxy-D-ribose 25°C, pH 7.5 Salmonella enterica subsp. enterica serovar Typhimurium
0.5
-
ATP 25°C, pH 7.5 Salmonella enterica subsp. enterica serovar Typhimurium
2
-
D-ribose 25°C, pH 7.5 Salmonella enterica subsp. enterica serovar Typhimurium
33.3
-
2-deoxy-D-ribitol 25°C, pH 7.5 Salmonella enterica subsp. enterica serovar Typhimurium

Metals/Ions

Metals/Ions Comment Organism Structure
Cd2+ can replace Mg2+ in activation, optimal concentration: 5 mM, 68% of the activity with Mg2+ Salmonella enterica subsp. enterica serovar Typhimurium
Co2+ can replace Mg2+ in activation, optimal concentration: 5 mM, 87% of the activity with Mg2+ Salmonella enterica subsp. enterica serovar Typhimurium
Cs+ optimal activity obtained in presence of 0.5 M NH4+ or Cs+ Salmonella enterica subsp. enterica serovar Typhimurium
Cu2+ can replace Mg2+ in activation, optimal concentration: 10 mM, 20% of the activity with Mg2+ Salmonella enterica subsp. enterica serovar Typhimurium
K+ stimulates Salmonella enterica subsp. enterica serovar Typhimurium
Mg2+ absolute requirement for divalent cations, best satisfied by Mg2+ Salmonella enterica subsp. enterica serovar Typhimurium
Mg2+ the change in the ratio from Mg2+ to ATP from 1 : 1 to 2 : 1 gives optimal activity Salmonella enterica subsp. enterica serovar Typhimurium
Mn2+ can replace Mg2+ in activation Salmonella enterica subsp. enterica serovar Typhimurium
Mn2+ optimal concentration 5 mM, 61% of the activity with Mg2+ Salmonella enterica subsp. enterica serovar Typhimurium
NH4+ optimal activity obtained in presence of 0.5 M NH4+ or Cs+ Salmonella enterica subsp. enterica serovar Typhimurium
Ni2+ can replace Mg2+, optimal concentration: 25-30 mM, 31% of the activity with Mg2+ Salmonella enterica subsp. enterica serovar Typhimurium
Rb+ stimulates Salmonella enterica subsp. enterica serovar Typhimurium
Zn2+ can replace Mg2+ in activation, optimal concentration: 1 mM, 27% of the activity with Mg2+ Salmonella enterica subsp. enterica serovar Typhimurium

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
33500
-
alpha2, 2 * 33500, SDS-PAGE Salmonella enterica subsp. enterica serovar Typhimurium
67800
-
high-speed sedimentation equilibrium method Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 2-deoxy-D-ribose Salmonella enterica subsp. enterica serovar Typhimurium first step in the inducible fermentation pathway for this sugar ADP + 2-deoxy-D-ribose 5-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. enterica serovar Typhimurium
-
deoxyribose-grown cells
-

Purification (Commentary)

Purification (Comment) Organism
-
Salmonella enterica subsp. enterica serovar Typhimurium

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
70
-
-
Salmonella enterica subsp. enterica serovar Typhimurium

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2-deoxy-D-ribitol 41% of the activity with 2-deoxy-D-ribose Salmonella enterica subsp. enterica serovar Typhimurium ADP + 2-deoxy-D-ribitol 5-phosphate
-
?
ATP + 2-deoxy-D-ribose
-
Salmonella enterica subsp. enterica serovar Typhimurium ADP + 2-deoxy-D-ribose 5-phosphate
-
?
ATP + 2-deoxy-D-ribose first step in the inducible fermentation pathway for this sugar Salmonella enterica subsp. enterica serovar Typhimurium ADP + 2-deoxy-D-ribose 5-phosphate
-
?
ATP + D-ribose
-
Salmonella enterica subsp. enterica serovar Typhimurium ADP + D-ribose 5-phosphate
-
?
CTP + D-ribose 18% of the activity with ATP Salmonella enterica subsp. enterica serovar Typhimurium CDP + D-ribose 5-phosphate
-
?
dATP + D-ribose 108% of the activity with ATP Salmonella enterica subsp. enterica serovar Typhimurium dADP + D-ribose 5-phosphate
-
?
dCTP + D-ribose 25% of the activity with ATP Salmonella enterica subsp. enterica serovar Typhimurium dCDP + D-ribose 5-phosphate
-
?
dGTP + D-ribose 50% of the activity with ATP Salmonella enterica subsp. enterica serovar Typhimurium dGDP + D-ribose 5-phosphate
-
?
GTP + D-ribose 32% of the activity with ATP Salmonella enterica subsp. enterica serovar Typhimurium GDP + D-ribose 5-phosphate
-
?
ITP + D-ribose 37% of the activity with ATP Salmonella enterica subsp. enterica serovar Typhimurium IDP + D-ribose 5-phosphate
-
?

Subunits

Subunits Comment Organism
dimer alpha2, 2 * 33500, SDS-PAGE Salmonella enterica subsp. enterica serovar Typhimurium

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Salmonella enterica subsp. enterica serovar Typhimurium

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8 7.2
-
Salmonella enterica subsp. enterica serovar Typhimurium