Literature summary for 2.7.1.149 extracted from

Noch, E.K.; Yim, I.; Milner, T.A.; Cantley, L.C.
Distribution and localization of phosphatidylinositol 5-phosphate, 4-kinase alpha and beta in the brain (2020), J. Comp. Neurol., 529, 434-449 .

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate	Mus musculus	-	ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	isoform PI5P4Kalpha is expressed in adulthood, whereas isoform PI5P4Kbeta is expressed early in development	Mus musculus	-
cerebral cortex	isoform PI5P4Kbeta is expressed in neuronal populations, especially hippocampus and cortex	Mus musculus	-
corpus callosum	isoform PI5P4Kalpha localizes to white matter tracts, especially the corpus callosum	Mus musculus	-
hippocampus	isoform PI5P4Kbeta is expressed in neuronal populations, especially hippocampus and cortex	Mus musculus	-
neuron	both isoforms PI5P4Kalpha and PI5P4Kbeta are contained in axon terminals and dendritic spines adjacent to the synaptic membrane	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate	-	Mus musculus	ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate	-	?

Synonyms

Synonyms	Comment	Organism
phosphatidylinositol 5-phosphate, 4-kinase alpha	isoform	Mus musculus
phosphatidylinositol 5-phosphate, 4-kinase beta	isoform	Mus musculus
PI5P4Kalpha	isoform	Mus musculus
PI5P4Kbeta	isoform	Mus musculus

General Information

General Information	Comment	Organism
physiological function	the enzyme isoforms play potential roles in synaptic transmission	Mus musculus

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Release 2023.1 (January 2023)