Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
nucleus | - |
Homo sapiens | 5634 | - |
spindle pole body | - |
Homo sapiens | 5816 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate | Homo sapiens | - |
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
CGL-2 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate | - |
Homo sapiens | ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 50000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
phosphatidylinositol-5-phosphate 4-kinase gamma | - |
Homo sapiens |
phosphatidylinositol-5-phosphate 4-kinase type-2 gamma | - |
Homo sapiens |
PIP4KIIgamma | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme depletion enhances the spindle pole accumulation of mitotic centromere-associated kinesin, a microtubule-depolymerizing kinesin, and results in a less stable spindle pole-associated microtubule | Homo sapiens |
physiological function | the enzyme is required for the assembly of bipolar spindles. The enzyme and phosphatidylinositol 4,5-bisphosphate may negatively regulate the microtubule depolymerization activity of mitotic centromere-associated kinesin by reducing polo-like kinase 1-mediated phosphorylation of mitotic centromere-associated kinesin | Homo sapiens |