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Literature summary for 2.7.1.149 extracted from
- Nuclear localizations of phosphatidylinositol 5-phosphate 4-kinases alpha and beta are dynamic and independently regulated during starvation-induced stress (2016), Biochem. J., 473, 2155-2163 .
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | isoform PI5P4Kalpha is predominantly (possible entirely) cytoplasmic when isoform PI5P4Kbeta is stably deleted from cells. In contrast, when PI5P4Kbeta is inducibly removed within 1 h PI5P4Kalpha retains its wild-type distribution of approximately 50:50 between cytoplasm and nucleus | Gallus gallus | 5737 | - |
| nucleus | isoform PI5P4Kalpha is chromatin-associated. In the exponential phase of growth PI5P4Kbeta is primarily cytoplasmic but translocates to the nucleus upon growth into the stationary phase or upon serum starvation | Gallus gallus | 5634 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 95000 | - |
isoform PI5P4Kgamma, gel filtration | Gallus gallus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate | Gallus gallus | - |
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Gallus gallus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| DT-40 cell | - |
Gallus gallus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate | - |
Gallus gallus | ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homodimer | 2 * 47000, isoform PI5P4Kgamma, SDS-PAGE | Gallus gallus |
| homodimer | 2 * 70000, enhanced monomeric green fluorescent protein-tagged isoform PI5P4Kalpha, SDS-PAGE | Gallus gallus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| phosphatidylinositol 5-phosphate 4-kinase | - |
Gallus gallus |
| PI5P4Kalpha | isoform | Gallus gallus |
| PI5P4Kbeta | isoform | Gallus gallus |
| PI5P4Kgamma | isoform | Gallus gallus |
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Release 2023.1 (January 2023)
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