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Literature summary for 2.7.1.148 extracted from

  • Tang, M.; Odejinmi, S.I.; Allette, Y.M.; Vankayalapati, H.; Lai, K.
    Identification of novel small molecule inhibitors of 4-diphosphocytidyl-2-C-methyl-D-erythritol (CDP-ME) kinase of Gram-negative bacteria (2011), Bioorg. Med. Chem., 19, 5886-5895.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
structure-activity relationship studies with inhibitors 6-(benzylsulfanyl)-2-(2-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-1,3-thiazine-5-carbonitrile and (4E)-3-methyl-4-[(5-phenylfuran-2-yl)methylidene]-1,2-oxazol-5(4H)-one Escherichia coli
structure-activity relationship studies with inhibitors 6-(benzylsulfanyl)-2-(2-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-1,3-thiazine-5-carbonitrile and (4E)-3-methyl-4-[(5-phenylfuran-2-yl)methylidene]-1,2-oxazol-5(4H)-one Yersinia pestis

Inhibitors

Inhibitors Comment Organism Structure
(4E)-3-methyl-4-[(5-phenylfuran-2-yl)methylidene]-1,2-oxazol-5(4H)-one
-
Escherichia coli
(4E)-3-methyl-4-[(5-phenylfuran-2-yl)methylidene]-1,2-oxazol-5(4H)-one
-
Yersinia pestis
(4Z)-4-(furan-2-ylmethylidene)-3-phenyl-1,2-oxazol-5(4H)-one
-
Escherichia coli
(4Z)-4-(furan-2-ylmethylidene)-3-phenyl-1,2-oxazol-5(4H)-one
-
Yersinia pestis
(4Z)-4-[(5-methylfuran-2-yl)methylidene]-3-phenyl-1,2-oxazol-5(4H)-one
-
Escherichia coli
(4Z)-4-[(5-methylfuran-2-yl)methylidene]-3-phenyl-1,2-oxazol-5(4H)-one
-
Yersinia pestis
6-(benzylsulfanyl)-2-(2-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-1,3-thiazine-5-carbonitrile at an external concentration of 50 microM, compound is able to inhibit the growth of Escherichia coli in culture for at least six hours Escherichia coli
6-(benzylsulfanyl)-2-(2-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-1,3-thiazine-5-carbonitrile
-
Yersinia pestis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.02
-
ATP pH not specified in the publication, 22°C Escherichia coli
0.2
-
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol pH not specified in the publication, 22°C Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Escherichia coli DH5-alpha
-
-
-
Yersinia pestis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
Escherichia coli ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
?
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
Yersinia pestis ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
?
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
Escherichia coli DH5-alpha ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
?

Synonyms

Synonyms Comment Organism
CDP-ME
-
Escherichia coli
CDP-ME
-
Yersinia pestis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0055
-
pH not specified in the publication, 22°C Escherichia coli (4E)-3-methyl-4-[(5-phenylfuran-2-yl)methylidene]-1,2-oxazol-5(4H)-one
0.006
-
pH not specified in the publication, 22°C Yersinia pestis (4E)-3-methyl-4-[(5-phenylfuran-2-yl)methylidene]-1,2-oxazol-5(4H)-one
0.007
-
pH not specified in the publication, 22°C Escherichia coli (4Z)-4-(furan-2-ylmethylidene)-3-phenyl-1,2-oxazol-5(4H)-one
0.008
-
pH not specified in the publication, 22°C Escherichia coli (4Z)-4-[(5-methylfuran-2-yl)methylidene]-3-phenyl-1,2-oxazol-5(4H)-one
0.009
-
pH not specified in the publication, 22°C Yersinia pestis 6-(benzylsulfanyl)-2-(2-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-1,3-thiazine-5-carbonitrile
0.012
-
pH not specified in the publication, 22°C Yersinia pestis (4Z)-4-(furan-2-ylmethylidene)-3-phenyl-1,2-oxazol-5(4H)-one
0.013
-
pH not specified in the publication, 22°C Yersinia pestis (4Z)-4-[(5-methylfuran-2-yl)methylidene]-3-phenyl-1,2-oxazol-5(4H)-one
0.018
-
pH not specified in the publication, 22°C Escherichia coli 6-(benzylsulfanyl)-2-(2-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-1,3-thiazine-5-carbonitrile