BRENDA - Enzyme Database show
show all sequences of 2.7.1.145

Non-viral deoxyribonucleoside kinases - diversity and practical use

Slot Christiansen, L.; Munch-Petersen, B.; Knecht, W.; J. Genet. Genomics 42, 235-248 (2015)

Data extracted from this reference:

Application
Application
Commentary
Organism
medicine
suicide gene dmdnk in several cancer cell lines, overview. In vivo testing in a xenograft model for breast cancer, both wild-type DmdNK and mutants of DmdNK are combined with gemcitabine (dFdC, 2',2'-difluoro-deoxycytidine) as the NA prodrug and a positive effect of decreasing tumor volume and increased survival time
Drosophila melanogaster
additional information
DmdNK broad substrate specificity and fast turnover rate make it an interesting candidate for suicide gene therapy, as well as in numerous biotechnological applications
Drosophila melanogaster
Crystallization (Commentary)
Crystallization
Organism
crystal structure determination, PDB IDs 1OE0, 1OT3, 1J90, 1ZM7, 1ZMX, 2JCS, 2VP0, 2VP2, 2VP4, 2VP, 2VP6, 2VP9, 2VPP, 2VQ, and 2JJ8
Drosophila melanogaster
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Bombyx mori
5829
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mg2+
required
Anopheles gambiae
Mg2+
required
Bombyx mori
Mg2+
required
Drosophila melanogaster
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + 2'-deoxyadenosine
Anopheles gambiae
-
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
?
ATP + 2'-deoxyadenosine
Drosophila melanogaster
-
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
?
ATP + 2'-deoxyadenosine
Bombyx mori
-
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
?
ATP + 2'-deoxycytidine
Anopheles gambiae
-
ADP + 2'-deoxycytidine 5'-phosphate
-
-
?
ATP + 2'-deoxycytidine
Drosophila melanogaster
-
ADP + 2'-deoxycytidine 5'-phosphate
-
-
?
ATP + 2'-deoxycytidine
Bombyx mori
-
ADP + 2'-deoxycytidine 5'-phosphate
-
-
?
ATP + 2'-deoxyguanosine
Anopheles gambiae
-
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
?
ATP + 2'-deoxyguanosine
Drosophila melanogaster
-
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
?
ATP + 2'-deoxyguanosine
Bombyx mori
-
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
?
ATP + 2'-deoxyribonucleoside
Anopheles gambiae
-
ADP + 2'-deoxyribonucleoside 5'-phosphate
-
-
?
ATP + 2'-deoxyribonucleoside
Drosophila melanogaster
-
ADP + 2'-deoxyribonucleoside 5'-phosphate
-
-
?
ATP + 2'-deoxyribonucleoside
Bombyx mori
-
ADP + 2'-deoxyribonucleoside 5'-phosphate
-
-
?
ATP + 2'-deoxythymidine
Anopheles gambiae
-
ADP + 2'-deoxythymidine 5'-phosphate
-
-
?
ATP + 2'-deoxythymidine
Drosophila melanogaster
-
ADP + 2'-deoxythymidine 5'-phosphate
-
-
?
ATP + 2'-deoxythymidine
Bombyx mori
-
ADP + 2'-deoxythymidine 5'-phosphate
-
-
?
additional information
Bombyx mori
the multisubstrate kinase from Bombyx mori (BmdNK) prefers pyrimidines
?
-
-
-
additional information
Drosophila melanogaster
the multisubstrate kinase from Drosophila prefers pyrimidines
?
-
-
-
additional information
Anopheles gambiae
the multisubstrate kinase from from Anopheles gambiae (AgdNK) prefers purines
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Anopheles gambiae
Q86LB8
gene dnk
-
Bombyx mori
Q9BKL3
gene dnk
-
Drosophila melanogaster
Q9XZT6
gene dnk
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + 2'-deoxyadenosine
-
738781
Anopheles gambiae
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyadenosine
-
738781
Drosophila melanogaster
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyadenosine
-
738781
Bombyx mori
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyadenosine
1% of the activity with 2'-deoxythymidine
738781
Drosophila melanogaster
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyadenosine
2.7% of the activity with 2'-deoxycytidine
738781
Bombyx mori
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyadenosine
48% of the activity with 2'-deoxythymidine
738781
Anopheles gambiae
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
ATP + 2'-deoxycytidine
-
738781
Anopheles gambiae
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
ATP + 2'-deoxycytidine
-
738781
Drosophila melanogaster
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
ATP + 2'-deoxycytidine
-
738781
Bombyx mori
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
ATP + 2'-deoxycytidine
best substrate
738781
Bombyx mori
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
ATP + 2'-deoxycytidine
88% of the activity with 2'-deoxythymidine
738781
Drosophila melanogaster
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
ATP + 2'-deoxycytidine
99% of the activity with 2'-deoxythymidine
738781
Anopheles gambiae
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyguanosine
-
738781
Anopheles gambiae
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyguanosine
-
738781
Drosophila melanogaster
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyguanosine
-
738781
Bombyx mori
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyguanosine
0.2% of the activity with 2'-deoxythymidine
738781
Drosophila melanogaster
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyguanosine
0.5% of the activity with 2'-deoxycytidine
738781
Bombyx mori
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyguanosine
83% of the activity with 2'-deoxythymidine
738781
Anopheles gambiae
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyribonucleoside
-
738781
Anopheles gambiae
ADP + 2'-deoxyribonucleoside 5'-phosphate
-
-
-
?
ATP + 2'-deoxyribonucleoside
-
738781
Drosophila melanogaster
ADP + 2'-deoxyribonucleoside 5'-phosphate
-
-
-
?
ATP + 2'-deoxyribonucleoside
-
738781
Bombyx mori
ADP + 2'-deoxyribonucleoside 5'-phosphate
-
-
-
?
ATP + 2'-deoxythymidine
-
738781
Anopheles gambiae
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
?
ATP + 2'-deoxythymidine
-
738781
Drosophila melanogaster
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
?
ATP + 2'-deoxythymidine
-
738781
Bombyx mori
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
?
ATP + 2'-deoxythymidine
best substrate
738781
Anopheles gambiae
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
?
ATP + 2'-deoxythymidine
best substrate
738781
Drosophila melanogaster
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
?
ATP + 2'-deoxythymidine
65% of the activity with 2'-deoxycytidine
738781
Bombyx mori
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
?
additional information
the multisubstrate kinase from Bombyx mori (BmdNK) prefers pyrimidines
738781
Bombyx mori
?
-
-
-
-
additional information
the multisubstrate kinase from Drosophila prefers pyrimidines
738781
Drosophila melanogaster
?
-
-
-
-
additional information
the multisubstrate kinase from from Anopheles gambiae (AgdNK) prefers purines
738781
Anopheles gambiae
?
-
-
-
-
additional information
substrate binding of non-TK1-like dNKs, overview
738781
Anopheles gambiae
?
-
-
-
-
additional information
substrate binding of non-TK1-like dNKs, overview
738781
Drosophila melanogaster
?
-
-
-
-
additional information
substrate binding of non-TK1-like dNKs, overview
738781
Bombyx mori
?
-
-
-
-
Cofactor
Cofactor
Commentary
Organism
Structure
ATP
-
Anopheles gambiae
ATP
-
Bombyx mori
ATP
-
Drosophila melanogaster
Application (protein specific)
Application
Commentary
Organism
medicine
suicide gene dmdnk in several cancer cell lines, overview. In vivo testing in a xenograft model for breast cancer, both wild-type DmdNK and mutants of DmdNK are combined with gemcitabine (dFdC, 2',2'-difluoro-deoxycytidine) as the NA prodrug and a positive effect of decreasing tumor volume and increased survival time
Drosophila melanogaster
additional information
DmdNK broad substrate specificity and fast turnover rate make it an interesting candidate for suicide gene therapy, as well as in numerous biotechnological applications
Drosophila melanogaster
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
ATP
-
Anopheles gambiae
ATP
-
Bombyx mori
ATP
-
Drosophila melanogaster
Crystallization (Commentary) (protein specific)
Crystallization
Organism
crystal structure determination, PDB IDs 1OE0, 1OT3, 1J90, 1ZM7, 1ZMX, 2JCS, 2VP0, 2VP2, 2VP4, 2VP, 2VP6, 2VP9, 2VPP, 2VQ, and 2JJ8
Drosophila melanogaster
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Bombyx mori
5829
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mg2+
required
Anopheles gambiae
Mg2+
required
Bombyx mori
Mg2+
required
Drosophila melanogaster
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + 2'-deoxyadenosine
Anopheles gambiae
-
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
?
ATP + 2'-deoxyadenosine
Drosophila melanogaster
-
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
?
ATP + 2'-deoxyadenosine
Bombyx mori
-
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
?
ATP + 2'-deoxycytidine
Anopheles gambiae
-
ADP + 2'-deoxycytidine 5'-phosphate
-
-
?
ATP + 2'-deoxycytidine
Drosophila melanogaster
-
ADP + 2'-deoxycytidine 5'-phosphate
-
-
?
ATP + 2'-deoxycytidine
Bombyx mori
-
ADP + 2'-deoxycytidine 5'-phosphate
-
-
?
ATP + 2'-deoxyguanosine
Anopheles gambiae
-
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
?
ATP + 2'-deoxyguanosine
Drosophila melanogaster
-
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
?
ATP + 2'-deoxyguanosine
Bombyx mori
-
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
?
ATP + 2'-deoxyribonucleoside
Anopheles gambiae
-
ADP + 2'-deoxyribonucleoside 5'-phosphate
-
-
?
ATP + 2'-deoxyribonucleoside
Drosophila melanogaster
-
ADP + 2'-deoxyribonucleoside 5'-phosphate
-
-
?
ATP + 2'-deoxyribonucleoside
Bombyx mori
-
ADP + 2'-deoxyribonucleoside 5'-phosphate
-
-
?
ATP + 2'-deoxythymidine
Anopheles gambiae
-
ADP + 2'-deoxythymidine 5'-phosphate
-
-
?
ATP + 2'-deoxythymidine
Drosophila melanogaster
-
ADP + 2'-deoxythymidine 5'-phosphate
-
-
?
ATP + 2'-deoxythymidine
Bombyx mori
-
ADP + 2'-deoxythymidine 5'-phosphate
-
-
?
additional information
Bombyx mori
the multisubstrate kinase from Bombyx mori (BmdNK) prefers pyrimidines
?
-
-
-
additional information
Drosophila melanogaster
the multisubstrate kinase from Drosophila prefers pyrimidines
?
-
-
-
additional information
Anopheles gambiae
the multisubstrate kinase from from Anopheles gambiae (AgdNK) prefers purines
?
-
-
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + 2'-deoxyadenosine
-
738781
Anopheles gambiae
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyadenosine
-
738781
Drosophila melanogaster
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyadenosine
-
738781
Bombyx mori
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyadenosine
1% of the activity with 2'-deoxythymidine
738781
Drosophila melanogaster
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyadenosine
2.7% of the activity with 2'-deoxycytidine
738781
Bombyx mori
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyadenosine
48% of the activity with 2'-deoxythymidine
738781
Anopheles gambiae
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
ATP + 2'-deoxycytidine
-
738781
Anopheles gambiae
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
ATP + 2'-deoxycytidine
-
738781
Drosophila melanogaster
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
ATP + 2'-deoxycytidine
-
738781
Bombyx mori
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
ATP + 2'-deoxycytidine
best substrate
738781
Bombyx mori
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
ATP + 2'-deoxycytidine
88% of the activity with 2'-deoxythymidine
738781
Drosophila melanogaster
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
ATP + 2'-deoxycytidine
99% of the activity with 2'-deoxythymidine
738781
Anopheles gambiae
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyguanosine
-
738781
Anopheles gambiae
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyguanosine
-
738781
Drosophila melanogaster
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyguanosine
-
738781
Bombyx mori
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyguanosine
0.2% of the activity with 2'-deoxythymidine
738781
Drosophila melanogaster
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyguanosine
0.5% of the activity with 2'-deoxycytidine
738781
Bombyx mori
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyguanosine
83% of the activity with 2'-deoxythymidine
738781
Anopheles gambiae
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyribonucleoside
-
738781
Anopheles gambiae
ADP + 2'-deoxyribonucleoside 5'-phosphate
-
-
-
?
ATP + 2'-deoxyribonucleoside
-
738781
Drosophila melanogaster
ADP + 2'-deoxyribonucleoside 5'-phosphate
-
-
-
?
ATP + 2'-deoxyribonucleoside
-
738781
Bombyx mori
ADP + 2'-deoxyribonucleoside 5'-phosphate
-
-
-
?
ATP + 2'-deoxythymidine
-
738781
Anopheles gambiae
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
?
ATP + 2'-deoxythymidine
-
738781
Drosophila melanogaster
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
?
ATP + 2'-deoxythymidine
-
738781
Bombyx mori
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
?
ATP + 2'-deoxythymidine
best substrate
738781
Anopheles gambiae
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
?
ATP + 2'-deoxythymidine
best substrate
738781
Drosophila melanogaster
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
?
ATP + 2'-deoxythymidine
65% of the activity with 2'-deoxycytidine
738781
Bombyx mori
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
?
additional information
the multisubstrate kinase from Bombyx mori (BmdNK) prefers pyrimidines
738781
Bombyx mori
?
-
-
-
-
additional information
the multisubstrate kinase from Drosophila prefers pyrimidines
738781
Drosophila melanogaster
?
-
-
-
-
additional information
the multisubstrate kinase from from Anopheles gambiae (AgdNK) prefers purines
738781
Anopheles gambiae
?
-
-
-
-
additional information
substrate binding of non-TK1-like dNKs, overview
738781
Anopheles gambiae
?
-
-
-
-
additional information
substrate binding of non-TK1-like dNKs, overview
738781
Drosophila melanogaster
?
-
-
-
-
additional information
substrate binding of non-TK1-like dNKs, overview
738781
Bombyx mori
?
-
-
-
-
General Information
General Information
Commentary
Organism
evolution
evolution of dNKs, overview. The two families of dNKs, the TK1-like kinases and the non-TK1-like kinases, have overall unique monomer structures and only share significant protein sequence similarity at the Ploop, a glycine rich ATP binding domain close to the N-terminus. This suggests that the two families have different evolutionary origins. The insect dNK is a non-TK1 like kinase
Anopheles gambiae
evolution
evolution of dNKs, overview. The two families of dNKs, the TK1-like kinases and the non-TK1-like kinases, have overall unique monomer structures and only share significant protein sequence similarity at the Ploop, a glycine rich ATP binding domain close to the N-terminus. This suggests that the two families have different evolutionary origins. The insect dNK is a non-TK1 like kinase
Bombyx mori
evolution
evolution of dNKs, overview. The two families of dNKs, the TK1-like kinases and the non-TK1-like kinases, have overall unique monomer structures and only share significant protein sequence similarity at the Ploop, a glycine rich ATP binding domain close to the N-terminus. This suggests that the two families have different evolutionary origins. The insect dNK is a non-TK1 like kinase
Drosophila melanogaster
additional information
structure of non-TK1 like kinases, overview
Anopheles gambiae
additional information
structure of non-TK1 like kinases, overview
Bombyx mori
additional information
structure of non-TK1 like kinases, overview
Drosophila melanogaster
physiological function
DmdNK is cell cycle regulated and under the control of cyclin E and the dE2F1 transcription factor, involved in G1/S phase transition
Drosophila melanogaster
General Information (protein specific)
General Information
Commentary
Organism
evolution
evolution of dNKs, overview. The two families of dNKs, the TK1-like kinases and the non-TK1-like kinases, have overall unique monomer structures and only share significant protein sequence similarity at the Ploop, a glycine rich ATP binding domain close to the N-terminus. This suggests that the two families have different evolutionary origins. The insect dNK is a non-TK1 like kinase
Anopheles gambiae
evolution
evolution of dNKs, overview. The two families of dNKs, the TK1-like kinases and the non-TK1-like kinases, have overall unique monomer structures and only share significant protein sequence similarity at the Ploop, a glycine rich ATP binding domain close to the N-terminus. This suggests that the two families have different evolutionary origins. The insect dNK is a non-TK1 like kinase
Bombyx mori
evolution
evolution of dNKs, overview. The two families of dNKs, the TK1-like kinases and the non-TK1-like kinases, have overall unique monomer structures and only share significant protein sequence similarity at the Ploop, a glycine rich ATP binding domain close to the N-terminus. This suggests that the two families have different evolutionary origins. The insect dNK is a non-TK1 like kinase
Drosophila melanogaster
additional information
structure of non-TK1 like kinases, overview
Anopheles gambiae
additional information
structure of non-TK1 like kinases, overview
Bombyx mori
additional information
structure of non-TK1 like kinases, overview
Drosophila melanogaster
physiological function
DmdNK is cell cycle regulated and under the control of cyclin E and the dE2F1 transcription factor, involved in G1/S phase transition
Drosophila melanogaster
Other publictions for EC 2.7.1.145
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
738739
Kamiya
In vivo selection of active de ...
Drosophila melanogaster
J. Biotechnol.
228
52-57
2016
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Use of Drosophila deoxynucleos ...
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Cytotoxic effect of Drosophila ...
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Drosophila melanogaster deoxyr ...
Drosophila melanogaster
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Structural studies of nucleosi ...
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A multisubstrate deoxyribonucl ...
Arabidopsis thaliana
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Functional studies of active-s ...
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Knecht
Drosophila deoxyribonucleoside ...
Drosophila melanogaster
Gene Ther.
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Non-homologous recombination o ...
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Solaroli
Mitochondrial expression of th ...
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Jordheim
Gemcitabine resistance due to ...
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672971
Legent
In vivo analysis of Drosophila ...
Drosophila melanogaster
Cell Cycle
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2006
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676247
Kamiya
Transient expression of Drosop ...
Drosophila melanogaster
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2006
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Welin
Structural basis for the chang ...
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661731
Piskur
Animal deoxyribonucleoside kin ...
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560
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662990
Solaroli
Investigation of the substrate ...
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660855
Krawiec
Inorganic tripolyphosphate (PP ...
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Biochem. Biophys. Res. Commun.
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Mikkelsen
Structural basis for feedback ...
Drosophila melanogaster
Biochemistry
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Solaroli
Active site mutants of Drosoph ...
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9
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Knecht
Mosquito has a single multisub ...
Anopheles gambiae
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662985
Krawiec
Ability of adenosine-2'(3')-de ...
Drosophila melanogaster
Nucleosides Nucleotides Nucleic Acids
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Eriksson
Structure and function of cell ...
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4
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4
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Knecht
A few amino acid substitutions ...
Drosophila melanogaster
Embo J.
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Knecht
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5
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660852
Zheng
Nucleoside analog cytotoxicity ...
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Johansson
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Munch-Petersen
Functional expression of a mul ...
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636843
Balzarini
The multifunctional deoxynucle ...
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3
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-
-
-
-
-
17
-
-
-
-
12
-
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-
-
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11
-
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1
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8
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-
-
-
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17
-
-
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12
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4
1
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15
-
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1
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15
17
-
4
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1
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4
1
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4
4
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4
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1
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1
1
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15
1
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-
1
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3
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-
-
-
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4
3
4
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2
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1
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1
1
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15
1
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1
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Four deoxynucleoside kinase ac ...
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5
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1
1
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1
1
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21
1
1
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4
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8
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4
8
5
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2
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1
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1
1
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21
1
1
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4
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