BRENDA - Enzyme Database show
show all sequences of 2.7.1.145

Mosquito has a single multisubstrate deoxyribonucleoside kinase characterized by unique substrate specificity

Knecht, W.; Petersen, G.E.; Sandrini, M.P.; Sondergaard, L.; Munch-Petersen, B.; Piskur, J.; Nucleic Acids Res. 31, 1665-1672 (2003)

Data extracted from this reference:

Application
Application
Commentary
Organism
medicine
enzyme with increased specificity towards certain analogues can be used as a suicide gene in combined gene/chemotherapy treatment of cancer
Anopheles gambiae
synthesis
enzyme can be utilized in industrial large-scale production of dNTPs and analogues, used for DNA synthetic reactions, giving a higher yield and less toxic byproducts compared to chemical processes
Anopheles gambiae
Cloned(Commentary)
Commentary
Organism
DNA and amino acid sequence determination and analysis, overexpression in TK-deficient Escherichia coli strain KY895 as GST-fusion protein
Anopheles gambiae
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0058
-
2'-deoxythymidine
pH 8.0, recombinant enzyme
Anopheles gambiae
0.0095
-
2'-deoxyguanosine
pH 8.0, recombinant enzyme
Anopheles gambiae
0.0126
-
2'-deoxycytidine
pH 8.0, recombinant enzyme
Anopheles gambiae
0.0181
-
2'-deoxyadenosine
pH 8.0, recombinant enzyme
Anopheles gambiae
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mg2+
-
Anopheles gambiae
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + 2'-deoxyadenosine
Anopheles gambiae
-
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
?
ATP + 2'-deoxycytidine
Anopheles gambiae
-
ADP + 2'-deoxycytidine 5'-phosphate
-
-
?
ATP + 2'-deoxyguanosine
Anopheles gambiae
-
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
?
ATP + 2'-deoxythymidine
Anopheles gambiae
-
ADP + 2'-deoxythymidine 5'-phosphate
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Anopheles gambiae
Q86LB8
-
-
Purification (Commentary)
Commentary
Organism
native enzyme from cell lines in a 5-step procedure, recombinant GST-fusion enzyme from Escherichia coli strain KY895 by GST-affinity chromatography
Anopheles gambiae
Source Tissue
Source Tissue
Commentary
Organism
Textmining
4a-2s4 cell
-
Anopheles gambiae
-
L3-5-3 cell
-
Anopheles gambiae
-
Sua1.1 cell
-
Anopheles gambiae
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
substrate specificities of cell lines
Anopheles gambiae
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + (E)-5-(2-bromovinyl)-2'-deoxyuridine
high activity
662967
Anopheles gambiae
ADP + (E)-5-(2-bromovinyl)-2'-deoxyuridine 5'-phosphate
-
-
-
?
ATP + 1-beta-D-arabinofuranosylcytosine
low activity
662967
Anopheles gambiae
ADP + 1-beta-D-arabinofuranosylcytosine 5'-phosphate
-
-
-
?
ATP + 1-beta-D-arabinofuranosylthymine
low activity
662967
Anopheles gambiae
ADP + 1-beta-D-arabinofuranosylthymine 5'-phosphate
-
-
-
?
ATP + 2',3'-didehydro-3'-deoxythymidine
low activity
662967
Anopheles gambiae
ADP + 2',3'-didehydro-3'-deoxythymidine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyadenosine
-
662967
Anopheles gambiae
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
ATP + 2'-deoxycytidine
-
662967
Anopheles gambiae
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
ATP + 2'-deoxycytidine
high activity
662967
Anopheles gambiae
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyguanosine
-
662967
Anopheles gambiae
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyguanosine
high activity
662967
Anopheles gambiae
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
-
?
ATP + 2'-deoxythymidine
-
662967
Anopheles gambiae
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
?
ATP + 2-chloro-2'-deoxyadenosine
best substrate
662967
Anopheles gambiae
ADP + 2-chloro-2'-deoxyadenosine 5'-phosphate
-
-
-
?
ATP + 5-fluoro-2'-deoxyuridine
-
662967
Anopheles gambiae
ADP + 5-fluoro-2'-deoxyuridine 5'-phosphate
-
-
-
?
ATP + stavudine
anti-HIV nucleoside analogue
662967
Anopheles gambiae
ADP + stavudine phosphate
-
-
-
?
additional information
substrate specificity, no activity with cytidine, adenine, guanine, and thymine, no activity with dideoxynucleosides, and with 3'-azido-2',3'-didehydro-3'-deoxythymidine
662967
Anopheles gambiae
?
-
-
-
-
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.014
-
2'-deoxythymidine
pH 8.0, recombinant enzyme
Anopheles gambiae
0.019
-
2'-deoxyguanosine
pH 8.0, recombinant enzyme
Anopheles gambiae
0.021
-
2'-deoxyadenosine
pH 8.0, recombinant enzyme
Anopheles gambiae
0.03
-
2'-deoxycytidine
pH 8.0, recombinant enzyme
Anopheles gambiae
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8
-
assay at
Anopheles gambiae
Cofactor
Cofactor
Commentary
Organism
Structure
ATP
-
Anopheles gambiae
Application (protein specific)
Application
Commentary
Organism
medicine
enzyme with increased specificity towards certain analogues can be used as a suicide gene in combined gene/chemotherapy treatment of cancer
Anopheles gambiae
synthesis
enzyme can be utilized in industrial large-scale production of dNTPs and analogues, used for DNA synthetic reactions, giving a higher yield and less toxic byproducts compared to chemical processes
Anopheles gambiae
Cloned(Commentary) (protein specific)
Commentary
Organism
DNA and amino acid sequence determination and analysis, overexpression in TK-deficient Escherichia coli strain KY895 as GST-fusion protein
Anopheles gambiae
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
ATP
-
Anopheles gambiae
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0058
-
2'-deoxythymidine
pH 8.0, recombinant enzyme
Anopheles gambiae
0.0095
-
2'-deoxyguanosine
pH 8.0, recombinant enzyme
Anopheles gambiae
0.0126
-
2'-deoxycytidine
pH 8.0, recombinant enzyme
Anopheles gambiae
0.0181
-
2'-deoxyadenosine
pH 8.0, recombinant enzyme
Anopheles gambiae
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mg2+
-
Anopheles gambiae
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + 2'-deoxyadenosine
Anopheles gambiae
-
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
?
ATP + 2'-deoxycytidine
Anopheles gambiae
-
ADP + 2'-deoxycytidine 5'-phosphate
-
-
?
ATP + 2'-deoxyguanosine
Anopheles gambiae
-
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
?
ATP + 2'-deoxythymidine
Anopheles gambiae
-
ADP + 2'-deoxythymidine 5'-phosphate
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
native enzyme from cell lines in a 5-step procedure, recombinant GST-fusion enzyme from Escherichia coli strain KY895 by GST-affinity chromatography
Anopheles gambiae
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
4a-2s4 cell
-
Anopheles gambiae
-
L3-5-3 cell
-
Anopheles gambiae
-
Sua1.1 cell
-
Anopheles gambiae
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
substrate specificities of cell lines
Anopheles gambiae
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + (E)-5-(2-bromovinyl)-2'-deoxyuridine
high activity
662967
Anopheles gambiae
ADP + (E)-5-(2-bromovinyl)-2'-deoxyuridine 5'-phosphate
-
-
-
?
ATP + 1-beta-D-arabinofuranosylcytosine
low activity
662967
Anopheles gambiae
ADP + 1-beta-D-arabinofuranosylcytosine 5'-phosphate
-
-
-
?
ATP + 1-beta-D-arabinofuranosylthymine
low activity
662967
Anopheles gambiae
ADP + 1-beta-D-arabinofuranosylthymine 5'-phosphate
-
-
-
?
ATP + 2',3'-didehydro-3'-deoxythymidine
low activity
662967
Anopheles gambiae
ADP + 2',3'-didehydro-3'-deoxythymidine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyadenosine
-
662967
Anopheles gambiae
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
ATP + 2'-deoxycytidine
-
662967
Anopheles gambiae
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
ATP + 2'-deoxycytidine
high activity
662967
Anopheles gambiae
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyguanosine
-
662967
Anopheles gambiae
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyguanosine
high activity
662967
Anopheles gambiae
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
-
?
ATP + 2'-deoxythymidine
-
662967
Anopheles gambiae
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
?
ATP + 2-chloro-2'-deoxyadenosine
best substrate
662967
Anopheles gambiae
ADP + 2-chloro-2'-deoxyadenosine 5'-phosphate
-
-
-
?
ATP + 5-fluoro-2'-deoxyuridine
-
662967
Anopheles gambiae
ADP + 5-fluoro-2'-deoxyuridine 5'-phosphate
-
-
-
?
ATP + stavudine
anti-HIV nucleoside analogue
662967
Anopheles gambiae
ADP + stavudine phosphate
-
-
-
?
additional information
substrate specificity, no activity with cytidine, adenine, guanine, and thymine, no activity with dideoxynucleosides, and with 3'-azido-2',3'-didehydro-3'-deoxythymidine
662967
Anopheles gambiae
?
-
-
-
-
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.014
-
2'-deoxythymidine
pH 8.0, recombinant enzyme
Anopheles gambiae
0.019
-
2'-deoxyguanosine
pH 8.0, recombinant enzyme
Anopheles gambiae
0.021
-
2'-deoxyadenosine
pH 8.0, recombinant enzyme
Anopheles gambiae
0.03
-
2'-deoxycytidine
pH 8.0, recombinant enzyme
Anopheles gambiae
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8
-
assay at
Anopheles gambiae
Other publictions for EC 2.7.1.145
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
738739
Kamiya
In vivo selection of active de ...
Drosophila melanogaster
J. Biotechnol.
228
52-57
2016
-
-
1
-
-
-
1
-
-
1
-
1
-
3
-
-
1
-
-
-
-
-
3
-
1
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
-
-
-
1
-
-
-
1
-
1
-
-
-
1
-
-
-
-
3
-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
738781
Slot Christiansen
Non-viral deoxyribonucleoside ...
Anopheles gambiae, Bombyx mori, Drosophila melanogaster
J. Genet. Genomics
42
235-248
2015
-
2
-
1
-
-
-
-
1
3
-
18
-
3
-
-
-
-
-
-
-
-
33
-
-
-
-
-
-
-
-
3
-
-
-
-
2
-
3
1
-
-
-
-
-
-
1
3
-
18
-
-
-
-
-
-
-
-
33
-
-
-
-
-
-
-
-
-
-
7
7
-
-
-
739211
Jiang
Tanshinone IIA enhances bystan ...
Drosophila melanogaster
Oncol. Rep.
34
1487-1493
2015
-
1
1
-
-
-
-
-
4
-
-
1
-
3
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
1
1
1
-
-
-
-
-
-
-
4
-
-
1
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
737404
Serra
-
Immobilized Drosophila melanog ...
Drosophila melanogaster
Adv. Synth. Catal.
356
563-570
2014
-
1
-
-
1
-
-
-
-
1
-
1
-
1
-
-
-
-
-
-
-
-
14
-
1
-
-
-
1
-
-
1
-
-
-
-
1
-
1
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
14
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
703396
Betham
Use of Drosophila deoxynucleos ...
Drosophila melanogaster
DNA Repair
9
153-160
2010
-
-
1
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
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-
-
-
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-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
721775
Ito
Cytotoxic effect of Drosophila ...
Drosophila melanogaster
Biol. Pharm. Bull.
33
1223-1227
2010
-
-
1
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
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-
1
-
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-
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-
-
-
-
-
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-
-
-
-
-
-
-
-
702047
Knecht
Drosophila melanogaster deoxyr ...
Drosophila melanogaster
Biochem. Biophys. Res. Commun.
382
430-433
2009
-
-
-
1
-
-
-
1
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
1
-
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-
-
1
1
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-
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1
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-
-
-
1
-
-
-
-
1
-
-
-
-
-
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-
1
1
692289
Mikkelsen
Structural studies of nucleosi ...
Drosophila melanogaster
FEBS J.
275
2151-2160
2008
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
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-
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1
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-
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-
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-
694476
Clausen
A multisubstrate deoxyribonucl ...
Arabidopsis thaliana
Nucleic Acids Symp. Ser.
52
489-490
2008
-
-
1
-
-
-
-
-
-
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2
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7
-
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1
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7
-
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-
-
-
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-
673584
Egeblad-Welin
Functional studies of active-s ...
Drosophila melanogaster
FEBS J.
274
1542-1551
2007
-
-
-
1
7
-
-
18
-
-
-
-
-
2
-
-
-
-
-
-
-
-
5
-
-
-
-
18
-
-
-
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-
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-
1
7
-
-
-
-
18
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
18
-
-
-
-
-
-
-
-
-
-
673848
Knecht
Drosophila deoxyribonucleoside ...
Drosophila melanogaster
Gene Ther.
14
1278-1286
2007
-
1
1
-
2
-
-
-
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
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-
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1
1
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2
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1
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-
-
-
-
-
675450
Gerth
Non-homologous recombination o ...
Drosophila melanogaster
J. Mol. Biol.
370
742-751
2007
-
-
-
-
1
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-
1
-
-
-
-
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1
-
-
1
-
-
-
-
-
6
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
6
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
676100
Solaroli
Mitochondrial expression of th ...
Drosophila melanogaster
Mol. Pharmacol.
72
1593-1598
2007
-
1
1
-
1
-
-
-
2
-
-
-
-
2
-
-
-
-
-
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672880
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Gemcitabine resistance due to ...
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672971
Legent
In vivo analysis of Drosophila ...
Drosophila melanogaster
Cell Cycle
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2006
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676247
Kamiya
Transient expression of Drosop ...
Drosophila melanogaster
Nucleosides Nucleotides Nucleic Acids
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2006
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Welin
Structural basis for the chang ...
Drosophila melanogaster
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661731
Piskur
Animal deoxyribonucleoside kin ...
Drosophila melanogaster
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662990
Solaroli
Investigation of the substrate ...
Drosophila melanogaster
Nucleosides Nucleotides Nucleic Acids
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10
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660855
Krawiec
Inorganic tripolyphosphate (PP ...
Drosophila melanogaster
Biochem. Biophys. Res. Commun.
301
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2003
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661072
Mikkelsen
Structural basis for feedback ...
Drosophila melanogaster
Biochemistry
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2003
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661629
Solaroli
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2003
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9
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9
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662967
Knecht
Mosquito has a single multisub ...
Anopheles gambiae
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2003
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662985
Krawiec
Ability of adenosine-2'(3')-de ...
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Nucleosides Nucleotides Nucleic Acids
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2003
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661453
Eriksson
Structure and function of cell ...
Bombyx mori, Drosophila melanogaster
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2002
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661583
Knecht
A few amino acid substitutions ...
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Knecht
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Zheng
Nucleoside analog cytotoxicity ...
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662932
Johansson
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Drosophila melanogaster
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636842
Munch-Petersen
Functional expression of a mul ...
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1
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636843
Balzarini
The multifunctional deoxynucle ...
Drosophila melanogaster
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Knecht
Identification of residues inv ...
Drosophila melanogaster
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Johansson
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636839
Munch-Petersen
The single deoxynucleoside kin ...
Drosophila melanogaster, Drosophila melanogaster S-2
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636840
Munch-Petersen
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